Reciprocal connectivity between secondary auditory cortical field and amygdala in mice.

Autor: Tsukano H; Department of Psychiatry, The University of North Carolina at Chapel Hill, 116 Manning Drive, Chapel Hill, NC, 27599, United States. tsukano-nii@umin.ac.jp.; Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8585, Japan. tsukano-nii@umin.ac.jp., Hou X; Laboratory of Neuronal Development, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Horie M; Department of Nursing, Niigata College of Nursing, 240 Shinnancho, Joetsu, 943-0147, Japan., Kitaura H; Department of Pathology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8585, Japan., Nishio N; Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8585, Japan.; Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Hishida R; Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8585, Japan., Takahashi K; Division of Otolaryngology, Graduate School of Medicine and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Kakita A; Department of Pathology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8585, Japan., Takebayashi H; Division of Neurobiology and Anatomy, Graduate School of Medicine and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Sugiyama S; Laboratory of Neuronal Development, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Shibuki K; Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8585, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2019 Dec 23; Vol. 9 (1), pp. 19610. Date of Electronic Publication: 2019 Dec 23.
DOI: 10.1038/s41598-019-56092-9
Abstrakt: Recent studies have examined the feedback pathway from the amygdala to the auditory cortex in conjunction with the feedforward pathway from the auditory cortex to the amygdala. However, these connections have not been fully characterized. Here, to visualize the comprehensive connectivity between the auditory cortex and amygdala, we injected cholera toxin subunit b (CTB), a bidirectional tracer, into multiple subfields in the mouse auditory cortex after identifying the location of these subfields using flavoprotein fluorescence imaging. After injecting CTB into the secondary auditory field (A2), we found densely innervated CTB-positive axon terminals that were mainly located in the lateral amygdala (La), and slight innervations in other divisions such as the basal amygdala. Moreover, we found a large number of retrogradely-stained CTB-positive neurons in La after injecting CTB into A2. When injecting CTB into the primary auditory cortex (A1), a small number of CTB-positive neurons and axons were visualized in the amygdala. Finally, we found a near complete absence of connections between the other auditory cortical fields and the amygdala. These data suggest that reciprocal connections between A2 and La are main conduits for communication between the auditory cortex and amygdala in mice.
Databáze: MEDLINE
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