Evidence of positively selected G6PD A- allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island.

Autor: Liang XY; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong Province, People's Republic of China.; Department of Medical Genetics, Shantou University Medical College, Shantou, Guangdong Province, People's Republic of China., Chen JT; The Chinese Medical Aid Team to the Republic of Equatorial Guinea, Guangzhou, Guangdong Province, People's Republic of China.; Department of Medical Laboratory, Huizhou Central Hospital, Huizhou, Guangdong Province, People's Republic of China., Ma YB; School of Mathematics and Statistics, Hanshan Normal University, Chaozhou, Guangdong Province, People's Republic of China., Huang HY; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong Province, People's Republic of China.; Department of Medical Genetics, Shantou University Medical College, Shantou, Guangdong Province, People's Republic of China., Xie DD; The Chinese Medical Aid Team to the Republic of Equatorial Guinea, Guangzhou, Guangdong Province, People's Republic of China.; Department of Medical Laboratory, Huizhou Central Hospital, Huizhou, Guangdong Province, People's Republic of China., Monte-Nguba SM; Department of Medical Laboratory, Malabo Regional Hospital, Malabo, Equatorial Guinea., Ehapo CS; Department of Medical Laboratory, Malabo Regional Hospital, Malabo, Equatorial Guinea., Eyi UM; Department of Medical Laboratory, Malabo Regional Hospital, Malabo, Equatorial Guinea., Zheng YZ; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong Province, People's Republic of China., Liu XZ; Department of Medical Laboratory, Chaozhou People's Hospital Affiliated to Shantou University Medical College, Chaozhou, Guangdong Province, People's Republic of China., Zha GC; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong Province, People's Republic of China., Lin LY; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong Province, People's Republic of China., Chen WZ; Department of Medical Laboratory, Chaozhou People's Hospital Affiliated to Shantou University Medical College, Chaozhou, Guangdong Province, People's Republic of China., Zhou X; Department of Medical Laboratory, Chaozhou People's Hospital Affiliated to Shantou University Medical College, Chaozhou, Guangdong Province, People's Republic of China., Lin M; School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong Province, People's Republic of China.; Department of Medical Laboratory, Chaozhou People's Hospital Affiliated to Shantou University Medical College, Chaozhou, Guangdong Province, People's Republic of China.
Jazyk: angličtina
Zdroj: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Feb; Vol. 8 (2), pp. e1061. Date of Electronic Publication: 2019 Dec 24.
DOI: 10.1002/mgg3.1061
Abstrakt: Background: Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme that protects red blood cells from oxidative damage. Although G6PD-deficient alleles appear to confer a protective effect of malaria, the link with clinical protection against Plasmodium infection is conflicting.
Methods: A case-control study was conducted on Bioko Island, Equatorial Guinea and further genotyping analysis used to detect natural selection of the G6PD A- allele.
Results: Our results showed G6PD A- allele could significantly reduce the risk of Plasmodium falciparum infection in male individuals (adjusted odds ratio [AOR], 0.43; 95% confidence interval [CI], 0.20-0.93; p < .05) and homozygous female individuals (AOR, 0.11; 95% CI, 0.01-0.84; p < .05). Additionally, the parasite densities were significantly different in the individuals with different G6PD A- alleles and individual levels of G6PD enzyme activity. The pattern of linkage disequilibrium and results of the long-range haplotype test revealed a strong selective signature in the region encompassing the G6PD A- allele over the past 6,250 years. The network of inferred haplotypes suggested a single origin of the G6PD A- allele in Africans.
Conclusion: Our findings demonstrate that glucose-6-phosphate dehydrogenase (G6PD) A- allele could reduce the risk of P. falciparum infection in the African population and indicate that malaria has a recent positive selection on G6PD A- allele.
(© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.)
Databáze: MEDLINE
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