Anaplastic variant of diffuse large B-cell lymphoma: Reappraisal as a nodal disease with sinusoidal involvement.

Autor: Megahed NA; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan.; Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Kohno K; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan., Sakakibara A; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan., Eladl AE; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan.; Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Elsayed AA; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan.; Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Wu CC; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan.; Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Suzuki Y; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan., Takahara T; Department of Surgical Pathology, Aichi Medical University Hospital, Aichi, Japan., Kato S; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Aichi, Japan., Nakamura S; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Aichi, Japan., Satou A; Department of Surgical Pathology, Aichi Medical University Hospital, Aichi, Japan., Asano N; Department of Clinical Laboratory, Nagano Prefectural Suzaka Hospital, Nagano, Japan.
Jazyk: angličtina
Zdroj: Pathology international [Pathol Int] 2019 Dec; Vol. 69 (12), pp. 697-705.
DOI: 10.1111/pin.12871
Abstrakt: Anaplastic variant (av) of diffuse large B-cell lymphoma (DLBCL) is morphologically defined in the 2017 World Health Organization classification, but still an enigmatic disease in its clinicopathologic distinctiveness, posing the differential diagnostic problem from gray zone lymphoma (GZL) and classic Hodgkin lymphoma (cHL). Thirty-one cases previously diagnosed as avDLBCL were reassessed. Of these, 27 (87%) and 4 (13%) were node-based and extranodal diseases, respectively. They were further reclassified into nodal avDLBCL (n = 18), nodal CD30+ DLBCL with T-cell/histiocyte-rich large B-cell lymphoma-like features (CD30+ DLBCL-THRLBCL) (n = 6), GZL with features intermediate between DLBCL and cHL (n = 3) and CD30+ extranodal DLBCL, NOS (n = 4). The nodal avDLBCL cases had a sheet-like proliferation of large cells and/or Hodgkin/Reed-Sternberg (HRS)-like cells in 12 (67%) notably with a sinusoidal pattern in 16 (89%). They showed an expression of CD20 and/or CD79a in all and CD30 in 15 of 18. All of them were negative for PD-L1 on tumor cells, although HRS-like cells showed negativity or partial loss of other B-cell markers to varying degrees. The present study highlighted the distinctiveness of the nodal avDLBCL with sinusoidal pattern, but without neoplastic PD-L1 expression, which provide refined diagnostic criteria for a more precise pathologic and clinical characterization of this disease.
(© 2019 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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