Centrifugal projections to the main olfactory bulb revealed by transsynaptic retrograde tracing in mice.

Autor: Schneider NY; Centre des Sciences du Goût et de l'Alimentation (CSGA), CNRS, INRAE, AgroSup Dijon, Université de Bourgogne Franche-Comté, F21000, Dijon, France., Chaudy S; Centre des Sciences du Goût et de l'Alimentation (CSGA), CNRS, INRAE, AgroSup Dijon, Université de Bourgogne Franche-Comté, F21000, Dijon, France., Epstein AL; UMR 1179 INSERM-UVSQ-End-icap, Université de Versailles-Saint Quentin en Yvelines, Versailles, France., Viollet C; Université de Paris, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, 'Synaptic plasticity and Neuronal Circuits', F-75014, Paris, France., Benani A; Centre des Sciences du Goût et de l'Alimentation (CSGA), CNRS, INRAE, AgroSup Dijon, Université de Bourgogne Franche-Comté, F21000, Dijon, France., Pénicaud L; Centre des Sciences du Goût et de l'Alimentation (CSGA), CNRS, INRAE, AgroSup Dijon, Université de Bourgogne Franche-Comté, F21000, Dijon, France., Grosmaître X; Centre des Sciences du Goût et de l'Alimentation (CSGA), CNRS, INRAE, AgroSup Dijon, Université de Bourgogne Franche-Comté, F21000, Dijon, France., Datiche F; Centre des Sciences du Goût et de l'Alimentation (CSGA), CNRS, INRAE, AgroSup Dijon, Université de Bourgogne Franche-Comté, F21000, Dijon, France., Gascuel J; Centre des Sciences du Goût et de l'Alimentation (CSGA), CNRS, INRAE, AgroSup Dijon, Université de Bourgogne Franche-Comté, F21000, Dijon, France.
Jazyk: angličtina
Zdroj: The Journal of comparative neurology [J Comp Neurol] 2020 Jul 15; Vol. 528 (11), pp. 1805-1819. Date of Electronic Publication: 2020 Jan 26.
DOI: 10.1002/cne.24846
Abstrakt: A wide range of evidence indicates that olfactory perception is strongly involved in food intake. However, the polysynaptic circuitry linking the brain areas involved in feeding behavior to the olfactory regions is not well known. The aim of this article was to examine such circuits. Thus, we described, using hodological tools such as transsynaptic viruses (PRV152) transported in a retrograde manner, the long-distance indirect projections (two to three synapses) onto the main olfactory bulb (MOB). The ß-subunit of the cholera toxin which is a monosynaptic retrograde tracer was used as a control to be able to differentiate between direct and indirect projections. Our tracing experiments showed that the arcuate nucleus of the hypothalamus, as a major site for regulation of food intake, sends only very indirect projections onto the MOB. Indirect projections to MOB also originate from the solitary nucleus which is involved in energy homeostasis. Other indirect projections have been evidenced in areas of the reward circuit such as VTA and accumbens nucleus. In contrast, direct projections to the MOB arise from melanin-concentrating hormone and orexin neurons in the lateral hypothalamus. Functional significances of these projections are discussed in relation to the role of food odors in feeding and reward-related behavior.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz: