Data on a genome-wide association study of type 2 diabetes in a Maya population.

Autor:	Totomoch-Serra A; Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional, Mexico City, Mexico.; PhD Program in Medical Sciences, Universidad de La Frontera, Chile., Domínguez-Cruz MG; Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional, Mexico City, Mexico., Muñoz ML; Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional, Mexico City, Mexico., García-Escalante MG; Laboratorios de Genética y Hematología, Centro de Investigaciones Regionales 'Dr. Hideyo Noguchi', Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico., Burgueño J; Centro Internacional de Mejoramiento de Maíz y Trigo. El Batán, Texcoco, State of Mexico, Mexico., Díaz-Badillo Á; Maestría en Salud Publica, Universidad México Americana Del Norte, Reynosa, Tamaulipas, Mexico.; Department of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas Health Science Center at Houston, Brownsville, TX, USA., Valadez-González N; Laboratorios de Genética y Hematología, Centro de Investigaciones Regionales 'Dr. Hideyo Noguchi', Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico., Escalante DP; Laboratorios de Genética y Hematología, Centro de Investigaciones Regionales 'Dr. Hideyo Noguchi', Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
Jazyk:	angličtina
Zdroj:	Data in brief [Data Brief] 2019 Nov 22; Vol. 28, pp. 104866. Date of Electronic Publication: 2019 Nov 22 (Print Publication: 2020).
DOI:	10.1016/j.dib.2019.104866
Abstrakt:	Maya communities have been shown to exhibit type 2 diabetes (T2D) with high prevalence compared with Mexican mestizo populations. Furthermore, some variants associated with the risk for T2D have been described. In this study, we describe the results of a pilot genome wide association study (GWAS) using 817,823 single nucleotide polymorphisms (SNPs) to identify candidate variants for replication in future studies. Herein, we present the GWAS study data, which were divided into three parts: first, 1289 ancestry informative markers (AIMs) were selected for Latino populations containing European, African, and Native American SNPs obtained from the literature; second, a GWAS hypothesis free to select candidate genes associated with T2D was performed, which identified 24 candidate genes; and third, 39 SNPs previously associated with T2D or related traits were replicated. This article is associated with the original article published in "Gene" under the title " Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population". (© 2019 The Author(s).)
Databáze:	MEDLINE
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