Oral Health and Cancer.

Autor: Chung M; Department of Public Health & Community Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111., York BR; Department of Public Health & Community Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111., Michaud DS; Department of Public Health & Community Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111.
Jazyk: angličtina
Zdroj: Current oral health reports [Curr Oral Health Rep] 2019 Jun; Vol. 6 (2), pp. 130-137. Date of Electronic Publication: 2019 Apr 15.
DOI: 10.1007/s40496-019-0213-7
Abstrakt: Purpose of Review: Recently published studies have provided new evidence for a role of oral health on risk of cancer. This review summarizes the latest research on this topic, including several new cohort studies that have examined associations on periodontal disease and cancer risk.
Recent Findings: The most consistent findings for associations with periodontal disease have been observed for lung cancer; five out of seven studies have reported statistically significant increases in risk of lung cancer. For pancreatic, colorectal and head and neck cancers, the associations are less consistent across studies, and the overall summary relative risk estimates are not statistically significant. However, these associations remain of interest, given the limitations of existing data (i.e., measurement error in periodontal disease assessment and small sample sizes), and growing support for biological mechanisms on how bacteria previously linked to periodontal disease may play a role in carcinogenesis.
Summary: Future studies need improved assessment of periodontal disease in population- based studies to determine if heterogeneity of current studies resides with measurement error. Periodontal disease treatment and prevention may turn out to be important targetable cancer prevention strategies.
Competing Interests: Conflict of Interest Mei Chung, Benjamin R. York, and Dominique S. Michaud each declare no conflict of interest.
Databáze: MEDLINE
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