Markers of endothelial injury and subclinical inflammation in children and adolescents with primary hypertension.

Autor:	Skrzypczyk P; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland., Ozimek A; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland., Ofiara A; Student Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland., Szyszka M; Student Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland., Sołtyski J; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland., Stelmaszczyk-Emmel A; Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland., Górska E; Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland., Pańczyk-Tomaszewska M; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Jazyk:	angličtina
Zdroj:	Central-European journal of immunology [Cent Eur J Immunol] 2019; Vol. 44 (3), pp. 253-261. Date of Electronic Publication: 2019 Sep 30.
DOI:	10.5114/ceji.2019.89597
Abstrakt:	Introduction: Adhesion molecules: E-selectin and intercellular adhesion molecule 1 (ICAM-1) are well-established markers of endothelial injury. The aim of the study was to assess the relation between E-selectin and ICAM-1 and clinical and biochemical parameters in children and adolescents with primary hypertension (PH). Material and Methods: In 77 patients with PH (15.04 ±2.62 years, 50 boys, 27 girls) we evaluated serum E-selectin, ICAM-1, and selected clinical and biochemical parameters including inflammatory indicators and ambulatory blood pressure monitoring (ABPM). Results: The E-selectin concentration was 55.63 ±26.49 ng/ml and the ICAM-1 concentration was 302.17 ±67.14 ng/ml. E-selectin and ICAM-1 correlated (p < 0.05) with BMI Z-score (r = 0.24, r = 0.29), ICAM-1 also with uric acid (r = 0.35), HDL-cholesterol (r = -0.28), platelet-to-lymphocyte ratio (r = 0.26), and systolic and mean blood pressure variability (r = 0.24, r = 0.24); in boys ICAM-1 correlated with mean platelet volume (r = 0.29). In multivariate analysis the only significant predictor of E-selectin was mean arterial pressure during 24 hours ( β = 0.329, 95% CI: 0.012-0.646) and of ICAM-1 - uric acid ( β = 0.430, 95% CI: 0.040-0.819). In 27 children with newly diagnosed PH E-selectin correlated negatively with diastolic blood pressure dipping (r = -0.54, p = 0.004) and positively with ambulatory arterial stiffness index (r = 0.51, p = 0.012). Conclusions: Elevated mean arterial pressure and hyperuricemia are risk factors of endothelial damage in paediatric patients with primary hypertension. In children with untreated primary hypertension there may be a relation between endothelial damage and disturbed circadian blood pressure profile. Competing Interests: The authors declare no conflict of interest. (Copyright: © 2019 Polish Society of Experimental and Clinical Immunology.)
Databáze:	MEDLINE
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