Correlation of Placental Magnetic Resonance Imaging With Histopathologic Diagnosis: Detection of Aberrations in Structure and Water Diffusivity.

Autor: Bockoven C; Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Evanston, Illinois., Gastfield RD; Center for Basic MR Research, Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois., Victor T; Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Evanston, Illinois., Venkatasubramanian PN; Center for Basic MR Research, Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois., Wyrwicz AM; Center for Basic MR Research, Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois., Ernst LM; Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Evanston, Illinois.
Jazyk: angličtina
Zdroj: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2020 Aug; Vol. 23 (4), pp. 260-266. Date of Electronic Publication: 2019 Dec 23.
DOI: 10.1177/1093526619895438
Abstrakt: Objective: Noninvasive methods to identify placental pathologic conditions are being sought in order to recognize these conditions at an earlier stage leading to improved clinical interventions and perinatal outcomes. The objective of this study was to examine fixed tissue slices of placenta by T 2 - and diffusion-weighted magnetic resonance imaging (MRI) and correlate the images with placental pathologic findings defined by routine gross and histologic examination.
Methods: Four formalin-fixed placentas with significant placental pathology (maternal vascular malperfusion, chronic villitis of unknown etiology, and massive perivillous fibrin deposition) and 2 histologically normal placentas were evaluated by high-resolution MRI. Representative placental slices were selected (2 cm long and 10 mm wide) and rehydrated. Imaging was performed on a Bruker Avance 14.1 T microimager. Diffusion-weighted images were acquired from 16 slices using slice thickness 0.5 mm and in-plane resolution approximately 100 µm × 100 µm. T 2 maps were obtained from the same slices. T 2 relaxation time and apparent diffusion coefficient (ADC) were acquired from representative regions of interest and compared between normal and diseased placentas.
Results: In T 2 - and diffusion-weighted images, the placental microstructure differed subjectively between diseased and normal placentas. Furthermore, diseased placentas showed statistically significantly longer mean T 2 relaxation times and generally higher mean ADC.
Conclusion: Diffusion- and T 2 -weighted MRI can potentially be used to detect significant placental pathology by using T 2 relaxation time and ADC as markers of altered placental microstructure.
Databáze: MEDLINE
Externí odkaz: