The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.

Autor: Gan-Or Z; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada., Rao T; Clinical Research Unit, Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Leveille E; Montreal Neurological Institute, McGill University, Montréal, QC, Canada.; Faculty of Medicine, McGill University, Montréal, QC, Canada., Degroot C; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Chouinard S; Unité des trouves du mouvement André Barbeau, Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada., Cicchetti F; Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, QC, Canada.; Département de Psychiatrie & Neurosciences, Université Laval, Québec, QC, Canada., Dagher A; Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Das S; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, Montreal, QC, Canada., Desautels A; Centre d'Études Avancées en Médecine du Sommeil and Neurology Service, H-pital du Sacré-C-eur de Montréal, Montréal, QC, Canada.; Department of Neurosciences, Université de Montréal, Montréal, QC, Canada., Drouin-Ouellet J; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, QC, Canada., Durcan T; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Gagnon JF; Centre d'Études Avancées en Médecine du Sommeil and Neurology Service, H-pital du Sacré-C-eur de Montréal, Montréal, QC, Canada.; Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada., Genge A; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada.; Clinical Research Unit, Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Karamchandani J; Department of Pathology, Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Lafontaine AL; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada.; Department of Neurology, McGill University Medical Centre, Montréal, QC, Canada., Sun SLW; Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Langlois M; Division of Neurosciences, CHU de Québec, Université Laval, Québec City, QC, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec City, QC, Canada., Levesque M; Département de Psychiatrie & Neurosciences, Université Laval, Québec, QC, Canada.; CERVO Brain Research Centre, Québec City, QC, Canada., Melmed C; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Jewish General Hospital, McGill University, Montréal, QC, Canada., Panisset M; Unité des trouves du mouvement André Barbeau, Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada., Parent M; Département de Psychiatrie & Neurosciences, Université Laval, Québec, QC, Canada.; CERVO Brain Research Centre, Québec City, QC, Canada., Poline JB; Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Postuma RB; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Pourcher E; Division of Neurosciences, CHU de Québec, Université Laval, Québec City, QC, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec City, QC, Canada., Rouleau GA; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada., Sharp M; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada., Monchi O; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Departments of Clinical Neurosciences and Radiology, University of Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, AB, Canada., Dupré N; Division of Neurosciences, CHU de Québec, Université Laval, Québec City, QC, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec City, QC, Canada., Fon EA; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Montreal Neurological Institute, McGill University, Montréal, QC, Canada.
Jazyk: angličtina
Zdroj: Journal of Parkinson's disease [J Parkinsons Dis] 2020; Vol. 10 (1), pp. 301-313.
DOI: 10.3233/JPD-191775
Abstrakt: Background: Genetic, biologic and clinical data suggest that Parkinson's disease (PD) is an umbrella for multiple disorders with clinical and pathological overlap, yet with different underlying mechanisms. To better understand these and to move towards neuroprotective treatment, we have established the Quebec Parkinson Network (QPN), an open-access patient registry, and data and bio-samples repository.
Objective: To present the QPN and to perform preliminary analysis of the QPN data.
Methods: A total of 1,070 consecutively recruited PD patients were included in the analysis. Demographic and clinical data were analyzed, including comparisons between males and females, PD patients with and without RBD, and stratified analyses comparing early and late-onset PD and different age groups.
Results: QPN patients exhibit a male:female ratio of 1.8:1, an average age-at-onset of 58.6 years, an age-at-diagnosis of 60.4 years, and average disease duration of 8.9 years. REM-sleep behavior disorder (RBD) was more common among men, and RBD was associated with other motor and non-motor symptoms including dyskinesia, fluctuations, postural hypotension and hallucinations. Older patients had significantly higher rates of constipation and cognitive impairment, and longer disease duration was associated with higher rates of dyskinesia, fluctuations, freezing of gait, falls, hallucinations and cognitive impairment. Since QPN's creation, over 60 studies and 30 publications have included patients and data from the QPN.
Conclusions: The QPN cohort displays typical PD demographics and clinical features. These data are open-access upon application (http://rpq-qpn.ca/en/), and will soon include genetic, imaging and bio-samples. We encourage clinicians and researchers to perform studies using these resources.
Databáze: MEDLINE
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