Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson's Disease: The ICICLE-PD Study.

Autor: Martin-Ruiz C; The NIHR Newcastle Biomedical Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK.; Biosciences Institute, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK., Williams-Gray CH; Department of Clinical Neurosciences, John Van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK., Yarnall AJ; The NIHR Newcastle Biomedical Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, UK.; The Newcastle upon Tyne Hospitals NHS Foundation Trust (NUTH), Newcastle Upon Tyne, UK., Boucher JJ; The NIHR Newcastle Biomedical Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK.; Current address: Department of Neurology, University College Hospital, Galway, Ireland., Lawson RA; Translational and Clinical Research Institute, Newcastle University, UK.; The Newcastle upon Tyne Hospitals NHS Foundation Trust (NUTH), Newcastle Upon Tyne, UK., Wijeyekoon RS; Department of Clinical Neurosciences, John Van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK., Barker RA; Department of Clinical Neurosciences, John Van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.; WT-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Kolenda C; The NIHR Newcastle Biomedical Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK., Parker C; The NIHR Newcastle Biomedical Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK., Burn DJ; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, The Newcastle upon Tyne Hospitals NHS Foundation Trust (NUTH), Newcastle Upon Tyne, UK., Von Zglinicki T; Biosciences Institute, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK., Saretzki G; Biosciences Institute, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK.
Jazyk: angličtina
Zdroj: Journal of Parkinson's disease [J Parkinsons Dis] 2020; Vol. 10 (1), pp. 193-206.
DOI: 10.3233/JPD-191724
Abstrakt: Background: Cognitive decline is a frequent complication of Parkinson's disease (PD) and the identification of predictive biomarkers for it would help in its management.
Objective: Our aim was to analyse whether senescence markers (telomere length, p16 and p21) or their change over time could help to better predict cognitive and motor progression of newly diagnosed PD patients. We also compared these senescence markers to previously analysed markers of inflammation for the same purpose.
Methods: This study examined the association of blood-derived markers of cell senescence and inflammation with motor and cognitive function over time in an incident PD cohort (the ICICLE-PD study). Participants (154 newly diagnosed PD patients and 99 controls) underwent physical and cognitive assessments over 36 months of follow up. Mean leukocyte telomere length and the expression of senescence markers p21 and p16 were measured at two time points (baseline and 18 months). Additionally, we selected five inflammatory markers from existing baseline data.
Results: We found that PD patients had shorter telomeres at baseline and 18 months compared to age-matched healthy controls which also correlated to dementia at 36 months. Baseline p16 levels were associated with faster rates of motor and cognitive decline over 36 months in PD cases, while a simple inflammatory summary score at baseline best predicted cognitive score over this same time period in PD patients.
Conclusion: Our study suggests that both inflammatory and senescence markers (p16) are valuable predictors of clinical progression in PD patients.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje