A prospective evaluation of health-related quality of life after skull base re-irradiation.

Autor: Bahig H; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ng SP; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Pollard C 3rd; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Nguyen TP; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Gunn GB; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rosenthal DI; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Fuller CD; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Frank SJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Garden AS; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Reddy JP; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Morrison WH; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ferrarotto R; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Hanna EY; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., DeMonte F; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Su SY; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Phan J; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2020 Mar; Vol. 42 (3), pp. 485-497. Date of Electronic Publication: 2019 Dec 23.
DOI: 10.1002/hed.26037
Abstrakt: Purpose: To report cancer control outcomes and health-related quality of life (HRQoL) outcomes after highly conformal skull-based re-irradiation (re-RT).
Methods: Patients planned for curative intent re-RT to a recurrent or new skull base tumor were enrolled. HRQoL were assessed using the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires.
Results: Thirty-nine patients were treated with stereotactic body RT or intensity modulated RT. Median follow-up was 14 months. Progression free survival was 71% at 1-year. There was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ) at the end of RT, followed by recovery to baseline on subsequent follow-ups. Subjective emotions were clinically improved at 12 months, with patients reporting feeling less tense/nervous.
Conclusion: Conformal skull base re-RT is associated with mild immediate deterioration in physical function followed by rapid and sustained recovery.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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