A prospective study examining isolated acne and acne with hyperandrogenic signs in adult females.

Autor: Bansal P; Department of Dermatology, Dr. Ram Manohar Lohia Hospital & Post Graduate Institute of Medical Education and Research New Delhi, New Delhi, India., Sardana K; Department of Dermatology, Dr. Ram Manohar Lohia Hospital & Post Graduate Institute of Medical Education and Research New Delhi, New Delhi, India., Sharma L; Department of Biochemistry, Dr. Ram Manohar Lohia Hospital & Post Graduate Institute of Medical Education and Research New Delhi, New Delhi, India., Garga UC; Department of Radiodiagnosis, Dr. Ram Manohar Lohia Hospital & Post Graduate Institute of Medical Education and Research New Delhi, New Delhi, India., Vats G; Department of Dermatology, Dr. Ram Manohar Lohia Hospital & Post Graduate Institute of Medical Education and Research New Delhi, New Delhi, India.
Jazyk: angličtina
Zdroj: The Journal of dermatological treatment [J Dermatolog Treat] 2021 Nov; Vol. 32 (7), pp. 752-755. Date of Electronic Publication: 2020 Jan 03.
DOI: 10.1080/09546634.2019.1708245
Abstrakt: Background: Adult female acne (AFA) occurs beyond 25 years of age and can present either as isolated acne or with hyperandrogenic signs.
Methods: 120 females aged ≥ 25 years were evaluated for acne, hirsutism and androgenetic alopecia. Hormonal assessment included total testosterone (TT), sex hormone binding globulin (SHBG), free androgen index (FAI), Anti Mullerian Hormone (AMH), 17-hydroxyprogesterone (17-OHP), dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH) and prolactin. Polycystic ovary syndrome (PCOS) was diagnosed using Rotterdam's criteria.
Results: The mean GAGS score was 15.57 ± 4.04.71.66% females had acne with hyperandrogenic signs (hirsutism, 55.81%; hyperseborrhoea, 65.12%; irregular menses, 36.05%) and 18.33% had increased androgen levels. The group with hyperandrogenic signs had longer duration of disease, truncal acne, significant adolescent acne history, stress, inappropriate diet and PCOS compared to the isolated acne group. The mean androgen levels were higher in the former but the difference was statistically insignificant.
Conclusions: Adult female acne can be associated with hyperandrogenic features though routine hormonal tests may not reveal an underlying abnormality except PCOS. End-organ hypersensitivity is the most plausible explanation and thus justifies the use of antiandrogens in its management.
Databáze: MEDLINE
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