Prospective of nanoscale metal organic frameworks [NMOFs] for cancer therapy.

Autor: Shait Mohammed MR; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Ahmad V; Health Information Technology Department,Faculty of Applied Studies, King Abdulaziz University, Jeddah, Saudi Arabia., Ahmad A; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Tabrez S; King Fahd Medical Research Center (KFMRC), King Abdulaziz University, Jeddah, Saudi Arabia., Choudhry H; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Cancer Metabolism and Epigenetic Unit, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Zamzami MA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Cancer Metabolism and Epigenetic Unit, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Bakhrebah MA; Life Science and Environmental Research Institute (KFMRC), King Abdulaziz City of Science and Technology (KACST), Riyadh 11442, Saudi Arabia., Ahmad A; Health Information Technology Department,Faculty of Applied Studies, King Abdulaziz University, Jeddah, Saudi Arabia., Wasi S; College of Medicine, Department of Biochemistry, Imam Abdul Rahman Bin Faisal Uuniversity, Dammam, Saudi Arabia., Mukhtar H; Department of Dermatology, University of Wisconsin, Madison, 4385 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA., Khan MI; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Cancer Metabolism and Epigenetic Unit, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Jazyk: angličtina
Zdroj: Seminars in cancer biology [Semin Cancer Biol] 2021 Feb; Vol. 69, pp. 129-139. Date of Electronic Publication: 2019 Dec 19.
DOI: 10.1016/j.semcancer.2019.12.015
Abstrakt: Nano metal organic frameworks (NMOFs) belong to the group of nanoporous materials. Over the decades, the conducted researches explored the area for the potential applications of NMOFs in areas like biomedical, chemical engineering and materials science. Recently, NMOFs have been explored for their potential use in cancer diagnosis and therapeutics. The excellent physico-chemical features of NMOFs also make them a potential candiadate to facilitate drug design, delivery and storage against cancer cells. In this review, we have explored the characterstic features, synthesis methods, NMOFs based drug delivery, diagnosis and imaging in various cancer types. In addition to this, we have also pondered on the stability and toxicological concerns of NMOFs. Despite, a significant research has been done for the potential use of NMOFs in cancer diagonostic and therapeutics, more information regarding the stability, in-vivo clearance, toxicology, and pharmacokinetics is still needed to ehnace the use of NMOFs in cancer diagonostic and therapeutics.
(Copyright © 2019. Published by Elsevier Ltd.)
Databáze: MEDLINE
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