Interleukin-17 acts in the hypothalamus reducing food intake.

Autor: Nogueira G; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Solon C; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Carraro RS; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Engel DF; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Ramalho AF; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Sidarta-Oliveira D; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Gaspar RS; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Bombassaro B; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Vasques AC; Laboratory of Investigation in Metabolism and Diabetes, University of Campinas, Campinas, Brazil., Geloneze B; Laboratory of Investigation in Metabolism and Diabetes, University of Campinas, Campinas, Brazil., Vinolo MA; Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Donato Junior J; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil., Velloso LA; Laboratory of Cell Signalling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil. Electronic address: lavellos@unicamp.br.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2020 Jul; Vol. 87, pp. 272-285. Date of Electronic Publication: 2019 Dec 18.
DOI: 10.1016/j.bbi.2019.12.012
Abstrakt: Interleukin-17 (IL-17) is expressed in the intestine in response to changes in the gut microbiome landscape and plays an important role in intestinal and systemic inflammatory diseases. There is evidence that dietary factors can also modify the expression of intestinal IL-17. Here, we hypothesized that, similar to several other gut-produced factors, IL-17 may act in the hypothalamus to modulate food intake. We confirm that food intake increases IL-17 expression in the mouse ileum and human blood. There is no expression of IL-17 in the hypothalamus; however, IL-17 receptor A is expressed in both pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons. Upon systemic injection, IL-17 promoted a rapid increase in hypothalamic POMC expression, which was followed by a late increase in the expression of AgRP. Both systemic and intracerebroventricular injections of IL-17 reduced calorie intake without affecting whole-body energy expenditure. Systemic but not intracerebroventricular injection of IL-17 increase brown adipose tissue temperature. Thus, IL-17 is a gut-produced factor that is controlled by diet and modulates food intake by acting in the hypothalamus. Our findings provide the first evidence of a cytokine that is acutely regulated by food intake and plays a role in the regulation of eating.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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