Comparison of clonazepam and levetiracetam in children for prevention of busulfan-induced seizure in hematopoietic stem cell transplantation.

Autor: Tsujimoto SI; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Shirai R; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Utano T; Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan., Osumi T; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Matsumoto K; Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan., Shioda Y; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Kiyotani C; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Uchiyama T; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Deguchi T; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Terashima K; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Tomizawa D; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Matsumoto K; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Kato M; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan. katom-tky@umin.ac.jp.
Jazyk: angličtina
Zdroj: International journal of hematology [Int J Hematol] 2020 Mar; Vol. 111 (3), pp. 463-466. Date of Electronic Publication: 2019 Dec 20.
DOI: 10.1007/s12185-019-02795-8
Abstrakt: Antiseizure prophylaxis is required during busulfan administration for hematopoietic stem cell transplantation. However, antiseizure agents such as benzodiazepines and phenytoin may produce adverse effects through interaction with other drugs. We retrospectively assessed the prophylactic efficacy and safety of levetiracetam and clonazepam against busulfan-induced seizures between 2013 and 2018. Thirty patients (after 2015) received levetiracetam, and 13 patients (before 2015) received clonazepam in this study. Levetiracetam was well-tolerated and had a significantly lower frequency of adverse effects, such as somnolence, compared with clonazepam, although two patients in the levetiracetam group experienced seizures. Levetiracetam is a feasible option for preventing busulfan-induced seizures.
Databáze: MEDLINE
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