| Autor: |
Oshida N; Division of Laboratory Medicine, Tsukuba University Hospital, Tsukuba, Ibaraki, 305-8576, Japan., Shida T; Tsukuba Preventive Medicine Research Center, Tsukuba University Hospital, Tsukuba, Ibaraki, 305-8576, Japan., Oh S; Tsukuba Sports Medicine and Health Science Center, Tsukuba University Hospital, Tsukuba, Ibaraki, 305-8576, Japan.; Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan., Kim T; Tsukuba Sports Medicine and Health Science Center, Tsukuba University Hospital, Tsukuba, Ibaraki, 305-8576, Japan., Isobe T; Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan., Okamoto Y; Division of Radiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan., Kamimaki T; Division of Laboratory Medicine, Tsukuba University Hospital, Tsukuba, Ibaraki, 305-8576, Japan., Okada K; Tsukuba Preventive Medicine Research Center, Tsukuba University Hospital, Tsukuba, Ibaraki, 305-8576, Japan., Suzuki H; Tsukuba Preventive Medicine Research Center, Tsukuba University Hospital, Tsukuba, Ibaraki, 305-8576, Japan., Ariizumi SI; Institute of Gastroenterology Surgery, Tokyo Women's Medical University, Tokyo, 162-8666, Japan., Yamamoto M; Institute of Gastroenterology Surgery, Tokyo Women's Medical University, Tokyo, 162-8666, Japan., Shoda J; Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. shodaj@md.tsukuba.ac.jp. |
| Abstrakt: |
Sarcopenia is a pathological condition affecting the development and progression of NAFLD. Urinary levels of titin-N fragment, a biomarker reflecting muscle damage, were measured in NAFLD subjects, and analyzed in a retrospective manner for possible correlations with NAFLD pathophysiology to assess their clinical relevance. This study enrolled 153 NAFLD subjects and 100 subjects without NAFLD, obesity or diabetes mellitus (non-NAFLD). NAFLD subjects had more decreased knee extension strength. NAFLD subjects had greater subcutaneous fat thickness and echo intensity (brightness) of the rectus femoris muscle on ultrasound images; higher levels of the intra- and extra-myocellular lipids (IMCL, EMCL) using 1 H-MRS. Urinary titin-N fragment levels were increased with increasing age but not different between males and females. NAFLD subjects had higher titin-N fragment levels than non-NAFLD subjects. The levels were negatively correlated with skeletal muscle mass and knee extension strength and positively correlated with muscle echo intensity, EMCL, and liver fibrosis scores (NAFLD fibrosis score, FIB-4 index). Multivariate analysis revealed that factors affecting the levels were skeletal mass index, leg skeletal muscle mass, liver stiffness, and NAFLD fibrosis score. Urinary levels of titin-N fragment reflected skeletal muscle deterioration and functional decline, and was closely associated with hepatic pathological conditions in NAFLD subjects. |
