| Autor: |
Fangzheng W; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences.; Department of Radiation Oncology, Zhejiang Cancer Hospital.; Key Laboratory of Radiation Oncology of Zhejiang Province., Chuner J; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Breast Tumor Surgery, Cancer Hospital of the University of Chinese Academy of Sciences.; Department of Breast Surgery, Zhejiang Cancer Hospital, Zhejiang, Hangzhou., Haiyan Q; Department of Radiation Oncology, People's Hospital of Kecheng, Zhejiang, Quzhou., Quanquan S; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences.; Department of Radiation Oncology, Zhejiang Cancer Hospital.; Key Laboratory of Radiation Oncology of Zhejiang Province., Zhimin Y; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences.; Department of Radiation Oncology, Zhejiang Cancer Hospital.; Key Laboratory of Radiation Oncology of Zhejiang Province., Tongxin L; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences.; Department of Radiation Oncology, Zhejiang Cancer Hospital.; Key Laboratory of Radiation Oncology of Zhejiang Province., Jiping L; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Physics., Peng W; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Pathology., Kaiyuan S; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Ultrasonography, Zhejiang Cancer Hospital, Zhejiang, Hangzhou., Zhenfu F; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences.; Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences.; Department of Radiation Oncology, Zhejiang Cancer Hospital.; Key Laboratory of Radiation Oncology of Zhejiang Province., Yangming J; Department of Digital Earth, Institute of Remote Sensing and Digital Earth, CAS, Beijing, People's Republic of China. |
| Abstrakt: |
Although induction chemotherapy (IC) combined with intensity-modulated radiotherapy (IMRT) plus concurrent chemotherapy (CC) is the new standard treatment option in locoregionally advanced nasopharyngeal carcinoma (NPC), many patients fail to receive CC. The aim of this study was to investigate long-term survival outcomes and toxicities in these patients who are treated with IC before IMRT without CC.We retrospectively reviewed 332 untreated, newly diagnosed locoregionally advanced NPC patients who received IC before IMRT alone at our institution from May 2008 through April 2014. The IC was administered every 3 weeks for 1 to 4 cycles. Acute and late radiation-related toxicities were graded according to the acute and late radiation morbidity scoring criteria of the radiation therapy oncology group. The accumulated survival was calculated according to the Kaplan-Meier method. The log-rank test was used to compare the difference in survival.With a median follow-up duration of 65 months (range: 8-110 months), the 5-year estimated locoregional relapse-free survival, distant metastasis-free survival, progression-free survival (PFS), and overall survival rates were 93.4%, 91.7%, 85.8%, and 82.5%, respectively. Older age and advanced T stage were adverse prognostic factors for overall survival, and the absence of comorbidity was a favorable prognostic factor for PFS. However, acceptable acute complications were observed in these patients.IC combined with IMRT alone provides promising long-term survival outcomes with manageable toxicities. Therefore, the omission of CC from the standard treatment did not affect survival outcomes. |
