Transmission control of schistosomiasis mansoni in a low endemicity area through a single intervention with rigorous prospection of infected cases treated with praziquantel: evaluation after 7 years of intervention.

Autor: Carneiro NFF; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.; Centro de Controle de Zoonoses, Montes Claros, Minas Gerais, Brazil., Caldeira AP; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil., Katz N; Fundação Oswaldo Cruz, Instituto René Rachou, Laboratório de Esquistossomose, Belo Horizonte, Minas Gerais, Brazil., Oliveira ÁA; Fundação Oswaldo Cruz, Instituto René Rachou, Laboratório de Esquistossomose, Belo Horizonte, Minas Gerais, Brazil., Siqueira LMV; Fundação Oswaldo Cruz, Instituto René Rachou, Laboratório de Esquistossomose, Belo Horizonte, Minas Gerais, Brazil., Oliveira E; Fundação Oswaldo Cruz, Instituto René Rachou, Laboratório de Pesquisa Clínica, Belo Horizonte, Minas Gerais, Brazil., Silveira MF; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil., Enk MJ; Instituto Evandro Chagas, Ananindeua, Pará, Brazil., Coelho PMZ; Fundação Oswaldo Cruz, Instituto René Rachou, Laboratório de Esquistossomose, Belo Horizonte, Minas Gerais, Brazil.
Jazyk: angličtina
Zdroj: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2019 Dec 20; Vol. 61, pp. e64. Date of Electronic Publication: 2019 Dec 20 (Print Publication: 2019).
DOI: 10.1590/S1678-9946201961064
Abstrakt: A prospective cohort study with rigorous searching for schistosomiasis cases was conducted among residents of Pedra Preta, Montes Claros, Minas Gerais State, Brazil, seven years after an intervention. Kato-Katz (KK), Saline Gradient, Miracidia Hatch and Polymerase Chain Reaction (PCR) were used as the diagnostic methods in 2008. In the period of 2013-2016, 175 patients remaining in the area were examined using the diagnostic methods Kato-Katz (24 slides, 1 g of feces) and Saline Gradient (2 procedures, 1 g of feces). Sixty-eight out of the 69 infected and treated individuals in 2008 tested negative. The percentage of new cases was 2.29% (4/175), and the 4 infected individuals presented low parasitic load [1, 6, 7 and 19 eggs per gram (EPG)]. All the participants answered epidemiological questionnaires on risky behavior. All residences had pit latrines and domiciliary water supply. The primary transmission focus (lake) was dry for several months. Malacological surveys showed a few non-infected specimens of Biomphalaria glabrata . A clear dominance of Biomphalaria straminea was observed. It can be inferred that a significant decrease in the disease transmission occurred after a single action through an intense search for infected and treated cases under the ecoepidemiological conditions of this area.
Databáze: MEDLINE