[Prevalence of extended-spectrum beta-lactamases in enterobacteria of neonatal sepsis and associated factors].

Autor:	Lona-Reyes JC; Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, Jalisco, México., Pérez-Ramírez RO; División de Pediatría, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca', Guadalajara, Jalisco, México., Rodríguez-Patiño V; División de Pediatría, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca', Guadalajara, Jalisco, México., Cordero-Zamora A; Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, Jalisco, México., Gómez-Ruiz LM; División de Pediatría, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca', Guadalajara, Jalisco, México., Llamas-Ramos L; División de Pediatría, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca', Guadalajara, Jalisco, México.
Jazyk:	Spanish; Castilian
Zdroj:	Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia [Rev Chilena Infectol] 2019 Aug; Vol. 36 (4), pp. 433-441.
DOI:	10.4067/S0716-10182019000400433
Abstrakt:	Background: Infections caused by extended-spectrum beta-lactamases enterobacteria (ESBL-EP) have implications for neonatal morbidity and mortality. Aim: To describe the prevalence of ESBL-EP in neonatal sepsis and associated factors. Methods: A prospective cohort study was conducted from August 2016 to August 2017; newborn babies (NB) hospitalized in the Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" were included. The ESBL-EP were investigated by double-disk synergy test and its association with clinical and demographic characteristics of the NB. Results: A total of 1,501 hospitalized NB were studied, with an average gestational age of 36.3 weeks. They were diagnosed 196 neonatal sepsis events, the most frequent etiologies were enterobacteria (45.5%). Resistance to ampicilin was found in 88.8% and to broad spectrum cephalosporins in more than 42% of the strains; 22.9% of them were ESBL phenotype. Apgar ≤ 7 at five minutes of life (OR 4.6; 95% CI 1.47-14.6) and gestational age < 37 weeks (OR 5.4; 95% CI 1.04-27.) increase the risk. Conclusion: In enterobacteria that cause neonatal sepsis, 22.9% were EP-ESBL; infection was more likely in patients with Apgar ≤ 7 at five minutes of age and in preterm infants.
Databáze:	MEDLINE
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