Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes.
| Autor: | Li L; State Key Laboratory of Nonlinear Mechanics and Beijing Key Laboratory of Engineered Construction and Mechanobiology , Institute of Mechanics, Chinese Academy of Sciences , Beijing 100190 , China., Hu J; Kuang Yaming Honors School & Institute for Brain Sciences , Nanjing University , Nanjing 210023 , China., Różycki B; Institute of Physics, Polish Academy of Sciences , Al. Lotników 32/46 , 02-668 Warsaw , Poland., Song F; State Key Laboratory of Nonlinear Mechanics and Beijing Key Laboratory of Engineered Construction and Mechanobiology , Institute of Mechanics, Chinese Academy of Sciences , Beijing 100190 , China.; School of Engineering Science , University of Chinese Academy of Sciences , Beijing 100049 , China. |
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| Jazyk: | angličtina |
| Zdroj: | Nano letters [Nano Lett] 2020 Jan 08; Vol. 20 (1), pp. 722-728. Date of Electronic Publication: 2019 Dec 24. |
| DOI: | 10.1021/acs.nanolett.9b04596 |
| Abstrakt: | Nanoscale molecular clusters in cell membranes can serve as platforms to recruit membrane proteins for various biological functions. A central question is how these nanoclusters respond to physical contacts between cells. Using a statistical mechanics model and Monte Carlo simulations, we explore how the adhesion of cell membranes affects the stability and coalescence of clusters enriched in receptor proteins. Our results show that intercellular receptor-ligand binding and membrane shape fluctuations can lead to receptor aggregation within the adhering membranes even if large-scale clusters are thermodynamically unstable in nonadhering membranes. |
| Databáze: | MEDLINE |
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