| Autor: |
Doaei S; Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran.; Department of Public Health, School of Health, Guilan University of Medical Sciences, Rasht, Iran., Mosavi Jarrahi SA; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Sanjari Moghadam A; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Akbari ME; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Javadi Kooshesh S; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Badeli M; Department of Nutrition, Urmia University of Medical Science, Urmia, Iran., Azizi Tabesh G; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Abbas Torki S; Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of MedicalSciences, Shiraz, Iran., Gholamalizadeh M; Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Zhu ZH; School of Public Health, Peking Union Medical College Beijing, Beijing China., Montazeri F; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mirzaei Dahka S; Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran. |
| Abstrakt: |
Obesity is associated with polymorphisms of the fat mass and obesity associated gene (FTO). This meta-analysis aimed to investigate the association of the rs9930506 FTO gene polymorphism and obesity. To the best of our knowledge, this study is the first meta-analysis to evaluate the relation between FTO rs9930506 polymorphism and obesity. We searched PubMed, Web of Science, and Embase to identify studies investigating the relations between the rs9930506 FTO gene polymorphism and obesity risk. We pooled adjusted odds ratios (OR) as overall and in continent subgroups. A Fixed-effects model was used to analyze the results of these studies in dominant and recessive models. By examining 3337 obesity cases and 3159 healthy controls, we identified 8 eligible case-control studies. Considering the dominant model of inheritance, there was a relationship between the rs9939506 polymorphism and obesity (OR=1.34 [1.03- 1.74]). The association remained significant in the European subgroup (OR=1.68 [1.2-2.36]), but not in the Asian subgroup. Using the recessive model, we also found a significant relationship when the overall association was investigated (OR=2.47; 95% CI 1.56-3.91). In conclusion, this study identified that the carriers of the risk allele of FTO rs9930506 polymorphism are at higher risk for obesity. |
