Assessment of the ecotoxicity of the pharmaceuticals bisoprolol, sotalol, and ranitidine using standard and behavioral endpoints.

Autor: Godoy AA; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo (USP), Avenida Professor Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil.; Science and Technology Institute, Federal University of Alfenas (Unifal-MG), Rodovia José Aurélio Vilela, 11,999, Poços de Caldas, MG, 37715-400, Brazil., Domingues I; Department of Biology & CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal., de Carvalho LB; Faculty of Economics, Administration and Accounting at Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes, 3900, Ribeirão Preto, SP, 14040-905, Brazil.; Federal Institute of Education, Science and Technology of Espírito Santo (IFES) Campus Barra de São Francisco, Rua Herculano Fernandes de Jesus, 111-Irmãos Fernandes, Barra de São Francisco, ES, 29800-000, Brazil., Oliveira ÁC; School of Technology, State University of Campinas (Unicamp), Rua Paschoal Marmo, 1888-Jardim Esmeralda, Limeira, SP, 13484-461, Brazil., de Jesus Azevedo CC; School of Technology, State University of Campinas (Unicamp), Rua Paschoal Marmo, 1888-Jardim Esmeralda, Limeira, SP, 13484-461, Brazil., Taparo JM; School of Technology, State University of Campinas (Unicamp), Rua Paschoal Marmo, 1888-Jardim Esmeralda, Limeira, SP, 13484-461, Brazil., Assano PK; School of Technology, State University of Campinas (Unicamp), Rua Paschoal Marmo, 1888-Jardim Esmeralda, Limeira, SP, 13484-461, Brazil., Mori V; School of Technology, State University of Campinas (Unicamp), Rua Paschoal Marmo, 1888-Jardim Esmeralda, Limeira, SP, 13484-461, Brazil., de Almeida Vergara Hidalgo V; School of Technology, State University of Campinas (Unicamp), Rua Paschoal Marmo, 1888-Jardim Esmeralda, Limeira, SP, 13484-461, Brazil., Nogueira AJA; Department of Biology & CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal., Kummrow F; Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo (USP), Avenida Professor Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil. fkummrow@unifesp.br.; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Rua São Nicolau, 210, Diadema, SP, 09972-270, Brazil. fkummrow@unifesp.br.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2020 Feb; Vol. 27 (5), pp. 5469-5481. Date of Electronic Publication: 2019 Dec 18.
DOI: 10.1007/s11356-019-07322-0
Abstrakt: The pharmaceuticals bisoprolol (BIS), sotalol (SOT), and ranitidine (RAN) are among the most consumed pharmaceuticals worldwide and are frequently detected in different aquatic ecosystems. However, very few ecotoxicity data are available in the literature for them. To help fill these data gaps, toxicity tests with the algae Raphidocelis subcapitata, the macrophyte Lemna minor, the cnidarian Hydra attenuata, the crustacean Daphnia similis, and the fish Danio rerio were performed for assessing the ecotoxicity of these pharmaceuticals. Standard, as well as non-standard endpoint, was evaluated, including the locomotor behavior of D. rerio larvae. Results obtained for SOT and RAN showed that acute adverse effects are not expected to occur on aquatic organisms at the concentrations at which these pharmaceuticals are usually found in fresh surface waters. On the other hand, BIS was classified as hazardous to the environment in the acute III category. Locomotor behavior of D. rerio larvae was not affected by BIS and RAN. A disturbance on the total swimming distance at the dark cycle was observed only for larvae exposed to the highest test concentration of 500 mg L -1 of SOT. D. similis reproduction was affected by BIS with an EC 10 of 3.6 (0.1-34.0) mg L -1 . A risk quotient (RQ) of 0.04 was calculated for BIS in fresh surface water, considering a worst-case scenario. To the best of our knowledge, this study presents the first chronic toxicity data with BIS on non-target organisms.
Databáze: MEDLINE
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