Effect of low- and high-protein maternal diets during gestation on reproductive outcomes in the rat: a systematic review and meta-analysis.

Autor:	Ajuogu PK; School of Science and Technology, University of New England, Armidale, NSW, Australia., Wolden M; Physical Therapy Program, University of Jamestown, Fargo, ND., McFarlane JR; Centre for Bioactive Discovery in Health and Ageing, University of New England, Armidale, NSW, Australia., Hart RA; School of Science and Technology, University of New England, Armidale, NSW, Australia., Carlson DJ; School of Health, Medical and Applied Sciences, Central Queensland University Australia, North Rockhampton, QLD, Australia., Van der Touw T; School of Science and Technology, University of New England, Armidale, NSW, Australia., Smart NA; School of Science and Technology, University of New England, Armidale, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Journal of animal science [J Anim Sci] 2020 Jan 01; Vol. 98 (1).
DOI:	10.1093/jas/skz380
Abstrakt:	Studies with animal models have consistently demonstrated adverse health outcomes in offspring born following nutritional manipulation during gestation. However, the effects of gestational dietary protein modification on reproductive outcomes at birth are less clear. We, therefore, conducted a systematic review and meta-analysis of controlled trials to determine whether high- or low-protein diets are associated with altered reproductive outcomes in a commonly studied species, the rat. Included studies were identified through a systematic search using electronic databases and manual literature review to identify randomized studies published between June 1972 and March 2019. Thirty-two studies were identified and used to analyze the effects of low- and high-protein gestational diets on litter size, litter weight, gestational weight gain, and gestational feed intake. The results indicate that low-protein diets significantly reduced litter weight (P < 0.00001) and gestational weight gain (P < 0.0006), but did not influence litter size (P = 0.62) or gestational feed intake (P = 0.25). In contrast, high-protein diets were found to reduce gestational feed intake (P = 0.004) but did not influence litter size (P = 0.56), litter weight (P = 0.22), or gestational weight gain (P = 0.35). The results suggest that low but not high-protein gestational diets alter reproductive outcomes at birth in rats. (© The Author(s) 2019. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu