[Endometrial morphological characteristics in patients with hysteromyoma and chronic endometritis in infertility].

Autor:	Kazachkov EL; South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia., Voropaeva EE; South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia., Kazachkova EA; South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia., Zatvornitskaya AV; South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia., Dub AA; South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia., Miroshnichenko LE; South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia.
Jazyk:	ruština
Zdroj:	Arkhiv patologii [Arkh Patol] 2019; Vol. 81 (6), pp. 41-48.
DOI:	10.17116/patol20198106141
Abstrakt:	Objective: To characterize endometrial structural and functional state and receptivity in women with hysteromyoma (HM) and chronic endometritis (CE) in infertile couples. Material and Methods: A total of 130 patients who had HM and/or CE in an infertile couple were examined. Group 1 included 64 women with HM and CE; Group 2 consisted of 24 patients with HM; group 3 comprised 42 patients with EC. A control group included endometrial biopsy specimens from 20 healthy women planning a pregnancy. Results: Patients with HM and CE were found to develop endometrial dysfunction. Its structural signs were damage to the endometrial surface epithelium; intense stromal fibrosis with the high expression of type III and IV collagens; dysregulated processes of high angiogenesis; impaired maturation of pinopodia by the implantation window; high estrogen receptor (ER) expression in the nuclei of endometrial glandular and stromal cells; low progesterone receptor (PR) expression; and impaired secretory endometrial transformation. Conclusion: HM concurrent with CE is responsible for endometrial dysfunction. Its structural manifestations are mainly associated with CE.
Databáze:	MEDLINE
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