Evaluation of multiplexed biomarkers in assessment of CSF infiltration in pediatric acute lymphoblastic leukemia.

Autor: Mikhael NL; Department of Clinical & Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Seif H Gendi MA; Department of Clinical & Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Hassab H; Department of Pediatrics Faculty of Medicine, Alexandria University, Alexandria, Egypt., Megahed EA; Department of Clinical & Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Jazyk: angličtina
Zdroj: International journal of hematologic oncology [Int J Hematol Oncol] 2019 Aug 12; Vol. 8 (3), pp. IJH22. Date of Electronic Publication: 2019 Aug 12.
DOI: 10.2217/ijh-2019-0008
Abstrakt: Acute lymphoblastic leukemia (ALL) is a very common pediatric malignancy with high survival rates. The course of treatment is modified according to the occurrence of central nervous system (CNS) disease. Aim: To relate serum and cerebrospinal fluid levels of five biomarkers (matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10) at diagnosis to the development of CNS infiltration. Methods: The present study was carried on 64 children with ALL and 20 controls. Multiplexed cytokines were measured by Luminex technology (Matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10). Results: Significantly higher sMMP-9 and lower sCCL2 were found in patients who developed CNS leukemia. Conclusion: Serum multiplexed parameters at diagnosis of childhood ALL may predict of development of CNS leukemia.
Competing Interests: Financial & competing interests disclosures The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
(© 2019 Neveen Lewis Mikhael.)
Databáze: MEDLINE