Distinct mechanisms of signal processing by lamina I spino-parabrachial neurons.

Autor: Agashkov K; Department of Sensory Signaling, Bogomoletz Institute of Physiology, Kyiv, 01024, Ukraine., Krotov V; Department of Molecular Biophysics, Bogomoletz Institute of Physiology, Kyiv, 01024, Ukraine., Krasniakova M; Department of Sensory Signaling, Bogomoletz Institute of Physiology, Kyiv, 01024, Ukraine., Shevchuk D; Department of Sensory Signaling, Bogomoletz Institute of Physiology, Kyiv, 01024, Ukraine.; Kyiv Academic University, Kyiv, 03142, Ukraine., Andrianov Y; Department of Sensory Signaling, Bogomoletz Institute of Physiology, Kyiv, 01024, Ukraine.; Kyiv Academic University, Kyiv, 03142, Ukraine., Zabenko Y; Department of Sensory Signaling, Bogomoletz Institute of Physiology, Kyiv, 01024, Ukraine., Safronov BV; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. safronov@ibmc.up.pt.; Neuronal Networks Group, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, 4200-135, Portugal. safronov@ibmc.up.pt., Voitenko N; Department of Sensory Signaling, Bogomoletz Institute of Physiology, Kyiv, 01024, Ukraine.; Kyiv Academic University, Kyiv, 03142, Ukraine., Belan P; Department of Molecular Biophysics, Bogomoletz Institute of Physiology, Kyiv, 01024, Ukraine. pasha@biph.kiev.ua.; Kyiv Academic University, Kyiv, 03142, Ukraine. pasha@biph.kiev.ua.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2019 Dec 17; Vol. 9 (1), pp. 19231. Date of Electronic Publication: 2019 Dec 17.
DOI: 10.1038/s41598-019-55462-7
Abstrakt: Lamina I spino-parabrachial neurons (SPNs) receive peripheral nociceptive input, process it and transmit to the supraspinal centres. Although responses of SPNs to cutaneous receptive field stimulations have been intensively studied, the mechanisms of signal processing in these neurons are poorly understood. Therefore, we used an ex-vivo spinal cord preparation to examine synaptic and cellular mechanisms determining specific input-output characteristics of the neurons. The vast majority of the SPNs received a few direct nociceptive C-fiber inputs and generated one spike in response to saturating afferent stimulation, thus functioning as simple transducers of painful stimulus. However, 69% of afferent stimulation-induced action potentials in the entire SPN population originated from a small fraction (19%) of high-output neurons. These neurons received a larger number of direct Aδ- and C-fiber inputs, generated intrinsic bursts and efficiently integrated a local network activity via NMDA-receptor-dependent mechanisms. The high-output SPNs amplified and integrated the nociceptive input gradually encoding its intensity into the number of generated spikes. Thus, different mechanisms of signal processing allow lamina I SPNs to play distinct roles in nociception.
Databáze: MEDLINE
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