Dual property of chitosan blended copolymer membranes: Antidiabetic drug release profile and antimicrobial assay.

Autor: Jaisankar E; Department of Chemical Engineering, Coimbatore Institute of Technology, Coimbatore 641 014, Tamil Nadu, India., Pavithra ME; Department of Microbiology, Dr. N.G.P. Arts and Science College, Coimbatore 641 048, Tamil Nadu, India., Krishna S; Department of Chemical Engineering, National Institute of Technology, Surathkal 575 025, Karnataka, India., Thirumarimurugan M; Department of Chemical Engineering, Coimbatore Institute of Technology, Coimbatore 641 014, Tamil Nadu, India., Azarudeen RS; Department of Chemical Engineering, Coimbatore Institute of Technology, Coimbatore 641 014, Tamil Nadu, India. Electronic address: azarudeen.r@cit.edu.in.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2020 Feb 15; Vol. 145, pp. 42-52. Date of Electronic Publication: 2019 Dec 14.
DOI: 10.1016/j.ijbiomac.2019.12.038
Abstrakt: Membranes were fabricated from a blend of synthetic copolymer (thiourea, phenylhydrazine and formaldehyde) and chitosan to study the metformin drug release profile and its kinetics. The membranes were characterized with elemental, scanning electron microscopy, FTIR and 1 H NMR spectroscopy to identify the empirical formula & weight, surface morphology and functional group changes occurred during the incorporation of chitosan to the copolymer. The swelling behaviour, drug loading efficiency and drug release profile of the membranes were studied using UV-visible spectroscopy. The mechanical properties and in vitro degradation studies were also performed. The reactive sites, better porosity and larger surface area provided by chitosan to the copolymer led to higher drug loading efficiency and controlled drug release profile. Kinetic study revealed swelling and diffusion controlled mechanism for the membranes, which obtained from Ritger-Peppas and Higuchi model. The chitosan and its copolymer membranes were tested for antimicrobial assay using selective gram-positive and gram-negative bacterial and fungal strains. The CS-TPF-drug membranes showed an acceptable control of the growth of all the microbial species compared to CS, CS-drug and the standard metformin drug.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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