Identification and typing of cardiac amyloidosis by noninvasive imaging: Two cases for two patterns.

Autor: Nappi C; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy., Zampella E; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy., Volpe F; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy., De Risi M; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy., Piscopo L; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy., Ponsiglione A; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy., Imbriaco M; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy., Acampa W; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.; Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy., Petretta M; Department of Translational Medical Sciences, University Federico II, Naples, Italy., Cuocolo A; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy. cuocolo@unina.it.
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2020 Jun; Vol. 27 (3), pp. 915-920. Date of Electronic Publication: 2019 Dec 16.
DOI: 10.1007/s12350-019-01982-8
Abstrakt: Cardiac amyloidosis is a restrictive infiltrative cardiomyopathy burdened by high mortality. The two more common forms are immunoglobulin light-chain amyloidosis and transthyretin-related amyloidosis with different prognoses and treatments. However, distinguishing between them is challenging. Appropriate utilization of the different available imaging techniques in the evaluation of patients with known or suspected cardiac amyloidosis is mandatory. We report two cases with cardiac amyloidosis of different etiology and with distinct imaging patterns. In the first case, the negative 99m Tc-diphosphonate imaging was useful to support the diagnosis of cardiac amyloid light-chain; the second case emphasized the utility of whole-body scintigraphy in recognizing transthyretin-related cardiac amyloidosis and the potential role of cadmium-zinc-telluride SPECT imaging for the evaluation of segmental distribution of cardiac disease. Both cases support the growing interest in looking for noninvasive methods to type cardiac amyloidosis in the place of invasive myocardial biopsy highlighting both possibilities and limitations of available imaging techniques in diagnosis and treatment monitoring.
Databáze: MEDLINE
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