Gibbs free energy of protein-protein interactions correlates with ATP production in cancer cells.

Autor: Golas SM; Chemical Engineering Department, University of Massachusetts, Amherst, MA, USA., Nguyen AN; Microbiology Department, University of Massachusetts, Amherst, MA, USA., Rietman EA; College of Information and Computer Sciences, University of Massachusetts, Amherst, MA, USA.; Mechanical and Industrial Engineering Department, University of Massachusetts, Amherst, MA, USA., Tuszynski JA; Department of Physics, University of Alberta, Edmonton, AB, Canada. jtus@phys.ualberta.ca.; Department of Oncology, University of Alberta, Edmonton, AB, Canada. jtus@phys.ualberta.ca.; DIMEAS, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy. jtus@phys.ualberta.ca.
Jazyk: angličtina
Zdroj: Journal of biological physics [J Biol Phys] 2019 Dec; Vol. 45 (4), pp. 423-430. Date of Electronic Publication: 2019 Dec 16.
DOI: 10.1007/s10867-019-09537-1
Abstrakt: In this paper, we analyze several cancer cell types from two seemingly independent angles: (a) the over-expression of various proteins participating in protein-protein interaction networks and (b) a metabolic shift from oxidative phosphorylation to glycolysis. We use large data sets to obtain a thermodynamic measure of the protein-protein interaction network, namely the associated Gibbs free energy. We find a strong inverse correlation between the percentage of energy production via oxidative phosphorylation and the Gibbs free energy of the protein networks. The latter is a measure of functional dysregulation within the cell. Our findings corroborate earlier indications that signaling pathway upregulation in cancer cells is linked to the metabolic shift known as the Warburg effect; hence, these two seemingly independent characteristics of cancer phenotype may be interconnected.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje