Zika virus infection in pregnancy and infant growth, body composition in the first three months of life: a cohort study.

Autor: Soares F; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Abranches AD; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Villela L; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Lara S; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Araújo D; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Nehab S; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Silva L; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Amaral Y; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Junior SCG; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Pone S; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Lobkowicz L; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Clemente NS; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.; Department of Epidemiology, University of São Paulo, São Paulo, Brazil., Brasil P; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Nielsen-Saines K; Universidade da California -Pediatric Infectious Disease, UCLA, Los Angeles, California, USA., Pone M; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Brickley E; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Moreira ME; Instituto Fernandes Figueira/Instituto Nacional de Infectologia - Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil. bebethiff@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2019 Dec 16; Vol. 9 (1), pp. 19198. Date of Electronic Publication: 2019 Dec 16.
DOI: 10.1038/s41598-019-55598-6
Abstrakt: The implications of Zika Virus exposure in pregnancy for early infant growth remains poorly described. The main goal of this study is to compare the growth, body composition, and feeding modality of infants in the first three months of life by prenatal Zika Virus exposure status. We selected an analytical cohort of 115 infants born without microcephaly, comprising 56 infants with qRT-PCR confirmed exposure to ZIKV during gestation and 59 infants born to women with presumptively no evidence of ZIKV in pregnancy. Infants were evaluated at birth, 1 and 3 months of age in terms of anthropometrics, body composition All the results were adjusted by maternal age, maternal BMI and gestational age. We observe no differences between anthropometric measurements at birth. Mothers in exposed group showed higher BMI. At 1 month and 3 months of age there were differences in mid arm circumference, arm muscle circumference and fat free mass. Weight and length was less in the ZIKV exposed in pregnancy infants and statistically different at 3 month of age. The findings of this investigation provide new evidence that ZIKV exposure in pregnancy may be associated with differences in body composition.
Databáze: MEDLINE
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