The upper-airway microbiota and loss of asthma control among asthmatic children.

Autor: Zhou Y; Department of Medicine, University of Connecticut, Farmington, CT, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA., Jackson D; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA., Bacharier LB; Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St Louis, MO, 63110, USA., Mauger D; Department of Public Health Sciences, Penn State University, Hershey, PA, USA., Boushey H; Department of Medicine, University of California, San Francisco, CA, 94143, USA., Castro M; Department of Medicine, St. Louis Children's Hospital, Washington University School of Medicine, St Louis, MO, 63110, USA., Durack J; Department of Medicine, University of California, San Francisco, CA, 94143, USA., Huang Y; Department of Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Lemanske RF Jr; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA., Storch GA; Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St Louis, MO, 63110, USA., Weinstock GM; The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA., Wylie K; Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St Louis, MO, 63110, USA., Covar R; National Jewish Health, Denver, CO, 80206, USA., Fitzpatrick AM; Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Phipatanakul W; Asthma, Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Robison RG; Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA., Beigelman A; Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St Louis, MO, 63110, USA. beigelmana@wustl.edu.; Kipper Institute of Allergy and Immunology, Schneider Children's Medical Center, Tel Aviv University, 5891000, Tel Aviv, Israel. beigelmana@wustl.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2019 Dec 16; Vol. 10 (1), pp. 5714. Date of Electronic Publication: 2019 Dec 16.
DOI: 10.1038/s41467-019-13698-x
Abstrakt: The airway microbiome has an important role in asthma pathophysiology. However, little is known on the relationships between the airway microbiome of asthmatic children, loss of asthma control, and severe exacerbations. Here we report that the microbiota's dynamic patterns and compositions are related to asthma exacerbations. We collected nasal blow samples (n = 319) longitudinally during a clinical trial at 2 time-points within one year: randomization when asthma is under control, and at time of early loss of asthma control (yellow zone (YZ)). We report that participants whose microbiota was dominated by the commensal Corynebacterium + Dolosigranulum cluster at RD experience the lowest rates of YZs (p = 0.005) and have longer time to develop at least 2 episodes of YZ (p = 0.03). The airway microbiota have changed from randomization to YZ. A switch from the Corynebacterium + Dolosigranulum cluster at randomization to the Moraxella- cluster at YZ poses the highest risk of severe asthma exacerbation (p = 0.04). Corynebacterium's relative abundance at YZ is inversely associated with severe exacerbation (p = 0.002).
Databáze: MEDLINE