Severe haemolytic disease of a newborn with variant D mimicking blocked-D phenomenon.

Autor:	Das S; Clinical Hematology and Medical Oncology, Malabar Cancer Center, Thalassery, Kerala, India., Shastry S; Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India shameeshastry@gmail.com., Baliga PB; Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2019 Dec 15; Vol. 12 (12). Date of Electronic Publication: 2019 Dec 15.
DOI:	10.1136/bcr-2019-231891
Abstrakt:	Anti-D is still the most common antibody causing severe haemolytic disease of the fetus and newborn (HDFN). In a mother with a very high titer of anti-D, antibodies can coat and block the D antigens on the red blood cells of the newborn. This blocking phenomenon prevents agglutination of the D-positive red cells with the IgM anti-D typing reagent, giving false negative results. Here, we report the case of a newborn with variant D phenotype and severe HDFN, which mimicked the blocked-D phenomenon, which, at the first instance, confused both the treating clinicians and the transfusion service personnel. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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