The effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) use on cerebral glucose metabolism in multiple sclerosis: a pilot study.
| Autor: | Workman CD; Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA., Kindred JH; Department of Physical Therapy, Medical University of South Carolina, Charleston, SC 29425, USA., Boles Ponto LL; Department of Radiology, University of Iowa Health Clinics, Iowa City, IA 52242, USA., Kamholz J; Department of Neurology, University of Iowa Health Clinics, Iowa City, IA 52242, USA., Rudroff T; Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA.; Department of Neurology, University of Iowa Health Clinics, Iowa City, IA 52242, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2020 Apr; Vol. 45 (4), pp. 450-452. Date of Electronic Publication: 2019 Dec 16. |
| DOI: | 10.1139/apnm-2019-0634 |
| Abstrakt: | This exploratory pilot study investigated the effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on cerebral glucose metabolism in people with multiple sclerosis (PwMS). Compared with nonusers, THC users had hypermetabolism of 3 regions ( p < 0.039, d >1.17) in left temporal areas, while CBD users had hypometabolism of 5 regions ( p < 0.032, d > 1.31) in left temporal areas. This study highlights the need to discriminate between THC and CBD in future cannabis studies. Novelty Chronic THC and CBD use had disparate effects on cerebral glucose metabolism in PwMS. |
| Databáze: | MEDLINE |
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