Polyethylene glycol electrolyte lavage solution increases tablet dissolution of acetaminophen in an in vitro model mimicking acute poisoning.

Autor: Nordt SP; Chapman University, School of Pharmacy, Irvine, CA, United States of America; University of Southern California, Department of Emergency Medicine, Los Angeles, CA, United States of America; University of California, Irvine, Department of Emergency Medicine, Orange, CA, United States of America. Electronic address: spnordt@hotmail.com., Won KJ; Chapman University, School of Pharmacy, Irvine, CA, United States of America., Tomaszweski C; University of California, San Diego, Department of Emergency Medicine, San Diego, CA, United States of America; California Poison Control System - San Diego Division, San Diego, CA, United States of America., Clark RF; University of California, San Diego, Department of Emergency Medicine, San Diego, CA, United States of America; California Poison Control System - San Diego Division, San Diego, CA, United States of America.
Jazyk: angličtina
Zdroj: The American journal of emergency medicine [Am J Emerg Med] 2020 Feb; Vol. 38 (2), pp. 325-328. Date of Electronic Publication: 2019 Sep 12.
DOI: 10.1016/j.ajem.2019.158444
Abstrakt: Introduction: Polyethylene glycol electrolyte lavage solution (PEG-ELS) is similar to pharmaceutical solvent propylene glycol and used following acute poisonings for whole bowel irrigation (e.g., "body stuffing"). This raises concern of PEG-ELS increasing solubility following acute ingestions of non-sustained release xenobiotics in the stomach. We theorized PEG-ELS increases solubility of acetaminophen in an in vitro stomach model.
Material and Methods: An in vitro artificial stomach with 500 mL simulated gastric fluid and either 500 mL of sodium chloride 0.9% (group A) or 500 mL of PEG-ELS (group B). Ten non-sustained release acetaminophen tablets added with concentrations 0, 15, 45 and 90 min in triplicate. Mean concentrations and mean area under the curve (AUC) (mg-min/L to 90 min).
Results: In control group A (normal saline + simulated gastric fluid) mean acetaminophen concentrations 0, 3, 13 and 36 mg/L at 0, 15, 45 and 90 min, respectively. In group B (PEG-ELS + simulated gastric fluid) mean acetaminophen concentrations 0, 34, 109 and 136 mg/L at 0, 15, 45 and 90 min, respectively (p < 0.05). Mean AUC 0-90 1385 [95% C.I. 990.5-1779] mg-min/L in control group A compared to mean AUC 0-90 in group B (PEG-ELS) 7673 mg-min/L [95% C.I. 4832-10513] (p < 0.05).
Discussion: Group B (PEG-ELS) with significantly higher mean acetaminophen concentrations and greater mean AUC compared to control group A (normal saline).
Conclusion: We demonstrated increased mean acetaminophen concentrations and increased mean AUC of following exposure of PEG-ELS in an artificial stomach model.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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