Antimicrobial activity of eugenol against carbapenem-resistant Klebsiella pneumoniae and its effect on biofilms.
Autor: | Qian W; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, PR China., Sun Z; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, PR China., Wang T; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, PR China., Yang M; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, PR China., Liu M; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, PR China., Zhang J; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, PR China., Li Y; Ningbo Municipal Center for Disease Control and Prevention, Ningbo, 315010, PR China. Electronic address: marsliydnb@163.com. |
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Jazyk: | angličtina |
Zdroj: | Microbial pathogenesis [Microb Pathog] 2020 Feb; Vol. 139, pp. 103924. Date of Electronic Publication: 2019 Dec 11. |
DOI: | 10.1016/j.micpath.2019.103924 |
Abstrakt: | A preliminary study found that eugenol expressed an antibacterial activity against Klebsiella pneumoniae. However, the mechanism of action of eugenol against K. pneumoniae still remains unexplored. The aim of this study was to gain further insight into the antibacterial effect of eugenol against carbapenem-resistant Klebsiella pneumoniae (CRKP) and possible mode of action. Here, minimum inhibitory concentration (MIC) of eugenol against CRKP strains was determined using the agar dilution method. Moreover, variations in intracellular ATP concentration, intracellular pH (pH Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2019 Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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