Tyrosol prevents AlCl 3 induced male reproductive damage by suppressing apoptosis and activating the Nrf-2/HO-1 pathway.

Autor: Güvenç M; Department of Physiology, Faculty of Veterinary Science, Hatay Mustafa Kemal University, Hatay, Turkey., Cellat M; Department of Physiology, Faculty of Veterinary Science, Hatay Mustafa Kemal University, Hatay, Turkey., Gökçek İ; Department of Physiology, Faculty of Veterinary Science, Hatay Mustafa Kemal University, Hatay, Turkey., Arkalı G; Department of Physiology, Faculty of Veterinary Science, Firat University, Elazig, Turkey., Uyar A; Department of Pathology, Faculty of Veterinary Science, Hatay Mustafa Kemal University, Hatay, Turkey., Tekeli İO; Department of Pharmocology and Toxicology, Faculty of Veterinary Science, Hatay Mustafa Kemal University, Hatay, Turkey., Yavaş İ; Department of Reproduction and Artificial Insemination, Faculty of Veterinary Science, Hatay Mustafa Kemal University, Hatay, Turkey.
Jazyk: angličtina
Zdroj: Andrologia [Andrologia] 2020 Mar; Vol. 52 (2), pp. e13499. Date of Electronic Publication: 2019 Dec 12.
DOI: 10.1111/and.13499
Abstrakt: Aluminium is a ubiquitous element that occurs naturally in the soil making human exposure to it is unavoidable. Tyrosol is present in olive oil and is known to have antioxidant effects. Therefore, the present study explores the toxic effects of aluminium chloride (AlCl 3 ) and evaluates the possible protection by tyrosol in male rats. Testicular injury was induced by the administration of AlCl 3 (34 mg kg -1  day -1 ). Rats were treated with either tyrosol (20 mg kg -1 day -1 ) or AlCl3 (34 mg kg -1 day -1 ). The experiment lasted for 10 weeks. Biochemical, histopathological and protein expression profiles were determined to decipher the role of tyrosol in protecting the cellular damage. Further, histomorphometric analyses of testes showed deranged architecture along with other noted abnormalities. AlCl 3 group rats' testes showed decreased GSH levels, CAT activities, Nrf-2, HO-1, bcl-2 expressions and sperm motility whereas increased caspase-3 expressions, MDA levels, abnormal and dead/live sperm ratio. However, tyrosol treatment attenuated these changes. The present results demonstrate the beneficial role of tyrosol treatment in AlCl 3 induced testicular toxicity alterations of rat.
(© 2019 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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