Phytochemical and Antioxidant Studies on a Rare Rheum cordatum Losinsk. Species from Kazakhstan.

Autor: Zhumashova G; School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, 050012 Almaty, Kazakhstan., Kukula-Koch W; Department of Pharmacognosy, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland., Koch W; Department of Food and Nutrition, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, Poland., Baj T; School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, 050012 Almaty, Kazakhstan., Sayakova G; School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, 050012 Almaty, Kazakhstan., Shukirbekova A; Department of Pharmaceutical Disciplines, Astana Medical University, Beybitshilik 49A, 010000 Nur-Sultan, Kazakhstan., Głowniak K; Department of Cosmetology, University of Information Technology and Management in Rzeszów, Kielnarowa 386a, 36-020 Tyczyn, Poland., Sakipova Z; School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, 050012 Almaty, Kazakhstan.
Jazyk: angličtina
Zdroj: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2019 Nov 16; Vol. 2019, pp. 5465463. Date of Electronic Publication: 2019 Nov 16 (Print Publication: 2019).
DOI: 10.1155/2019/5465463
Abstrakt: An optimisation of extraction towards an increased antioxidant capacity and the study on the extracts' composition by HPLC-ESI-Q-TOF-MS were performed on different organs of a rarely studied plant: Rheum cordatum Losinsk (Polygonaceae) growing in Kazakhstan. More than 20 compounds from anthraquinones and phenolics were identified in an optimised method. The plant was proven to contain a wide variety of phenolic compounds (catechins, flavonoids, and their glucosides and phenolic acids) in contrast to the anthraquinone composition, which was mainly represented by emodin and its analogues. The results of the studies could determine the plant as a rich source of pharmacologically precious polyphenols. It was evidenced that the extracting solvents, the time of collection, and the organs tested affected both the chemical content and the antioxidant potential of the extracts. Ethanol : water (50 : 50 v / v ) was selected as the most beneficial extractant for all metabolites, and based on the principal component analysis of raw data, the radical scavenging potential of the plant was strictly related to the presence of epicatechin gallate (ECG), kaempferol glucoside, and epigallocatechin gallate (EGCG) occurring in this extract at the concentration of 1.69-5%, 0.16-0.47%, and 0.001-2.93%, respectively.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper.
(Copyright © 2019 Gulsim Zhumashova et al.)
Databáze: MEDLINE
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