Carbohydrate antigen 125 predicts pulmonary congestion in patients with ST-segment elevation myocardial infarction.

Autor:	Falcão FJA; Faculdade de Ciência, Educação e Tecnologia, Universidade de Pernambuco, Garanhuns, PE, Brasil.; Centro de Ciências Médicas, Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, PE, Brasil.; Unidade de Cardiologia Invasiva, Hospital Memorial São José, Rede D'Or São Luiz, Recife, PE, Brasil.; Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brasil., Oliveira FRA; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil.; Unidade de Cardiologia Invasiva, Hospital Memorial São José, Rede D'Or São Luiz, Recife, PE, Brasil.; Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brasil., Cantarelli F; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil.; Unidade de Cardiologia Invasiva, Hospital Memorial São José, Rede D'Or São Luiz, Recife, PE, Brasil.; Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brasil., Cantarelli R; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil.; Unidade de Cardiologia Invasiva, Hospital Memorial São José, Rede D'Or São Luiz, Recife, PE, Brasil.; Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brasil., Brito-Júnior P; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil., Lemos H; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil., Silva P; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil., Camboim I; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil., Freire MC; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil., Carvalho O; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil., Sobral-Filho DC; Pronto Socorro Cardiológico de Pernambuco, Universidade de Pernambuco, Recife, PE, Brasil.
Jazyk:	angličtina
Zdroj:	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2019 Dec 05; Vol. 52 (12), pp. e9124. Date of Electronic Publication: 2019 Dec 05 (Print Publication: 2019).
DOI:	10.1590/1414-431X20199124
Abstrakt:	Carbohydrate antigen 125 (CA125) has long been used as an ovarian cancer biomarker. However, because it is not specific for ovarian cells, CA125 could also be used to monitor congestion and inflammation in heart disease. Acute heart failure (HF) is used to identify patients with a worse prognosis in ST-segment elevation myocardial infarction (STEMI). We aimed to determine the association of CA125 with acute HF in STEMI and to compare CA125 with N-terminal pro brain natriuretic peptide (NTproBNP) with a cross-sectional study. At admission, patients were examined to define Killip class and then underwent coronary angioplasty. Blood samples, preferably taken in the hemodynamic ward, were centrifuged (1500 g for 15 min at ambient temperature) and stored at -80°C until biomarker assays were performed. Patients were divided into two groups according to the presence or absence of congestion. Patients in Killip class ≥II were in the congestion group and those with Killip
Databáze:	MEDLINE
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