Implant surface alters compartmental-specific contributions to fixation strength in rats.

Autor: Ko FC; Department of Cell & Molecular Medicine, Rush University Medical Center, Chicago, Illinois., Meagher MJ; Department of Cell & Molecular Medicine, Rush University Medical Center, Chicago, Illinois., Mashiatulla M; Department of Cell & Molecular Medicine, Rush University Medical Center, Chicago, Illinois.; Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois., Ross RD; Department of Cell & Molecular Medicine, Rush University Medical Center, Chicago, Illinois., Virdi AS; Department of Cell & Molecular Medicine, Rush University Medical Center, Chicago, Illinois., Sumner DR; Department of Cell & Molecular Medicine, Rush University Medical Center, Chicago, Illinois.
Jazyk: angličtina
Zdroj: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2020 Jun; Vol. 38 (6), pp. 1208-1215. Date of Electronic Publication: 2019 Dec 25.
DOI: 10.1002/jor.24561
Abstrakt: Mechanical fixation of the implant to host bone is an important contributor to orthopedic implant survivorship. The relative importance of bone-implant contact, trabecular bone architecture, and cortical bone geometry to implant fixation strength has never been directly tested, especially in the settings of differential implant surface properties. Thus, using a rat model where titanium rods were placed into the intramedullary canal of the distal femur, we determined the relative contribution of bone-implant contact and peri-implant bone architecture to the fixation strength in implants with different surface roughness: highly polished and smooth (as-received) and dual acid-etched (DAE) implants. Using a training set that maximized variance in implant fixation strength, we initially examined correlation between implant fixation strength and outcome parameters from microcomputed tomography and found that osseointegration volume per total volume (OV/TV), trabecular bone volume per total volume (BV/TV), and cortical thickness (Ct.Th) were the single best compartment-specific predictors of fixation strength. We defined separate regression models to predict implant fixation strength for as-received and DAE implants. When the training set models were applied to independent validation sets, we found strong correlations between predicted and experimentally measured implant fixation strength, with r 2  = .843 in as received and r 2  = .825 in DAE implants. Interestingly, for as-received implants, OV/TV explained more of the total variance in implant fixation strength than the other variables, whereas in DAE implants, Ct.Th had the most explanatory power, suggesting that surface topography of implants affects which bone compartment is most important in providing implant fixation strength.
(© 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)
Databáze: MEDLINE
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