Update on the pathology, genetics and somatic landscape of sebaceous tumours.

Autor: Ferreira I; Université Libre de Bruxelles, Brussels, Belgium.; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK., Wiedemeyer K; Department of Dermatology, University Hospital of Heidelberg, Heidelberg, Germany.; Department of Pathology & Laboratory Medicine, The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada., Demetter P; Department of Pathology, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium., Adams DJ; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK., Arends MJ; Division of Pathology, Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, The University of Edinburgh, Edinburgh, UK., Brenn T; Department of Pathology & Laboratory Medicine, The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Division of Pathology, Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, The University of Edinburgh, Edinburgh, UK.
Jazyk: angličtina
Zdroj: Histopathology [Histopathology] 2020 Apr; Vol. 76 (5), pp. 640-649. Date of Electronic Publication: 2020 Mar 17.
DOI: 10.1111/his.14044
Abstrakt: Cutaneous sebaceous neoplasms show a predilection for the head and neck area of adults and include tumours with benign behaviour, sebaceous adenoma and sebaceoma, and sebaceous carcinoma with potential for an aggressive disease course at the malignant end of the spectrum. The majority of tumours are solitary and sporadic, but a subset of tumours may be associated with Lynch syndrome, also known as hereditary non-polyposis colon cancer (HNPCC) and previously referred to as Muir-Torre syndrome (now known to be part of Lynch syndrome). This review provides an overview of the clinical and histological features of cutaneous sebaceous neoplasia with an emphasis on differentiating features and differential diagnosis. It also offers insights into the recently described molecular pathways involved in the development of sebaceous tumours and their association with Lynch syndrome.
(© 2020 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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