Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene- 1,4-dione).

Autor:	Novais JS; Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, Programa de Pos-graduacao em Patologia, 24033-900, Niteroi-RJ, Brazil., Rosandiski AC; Instituto Federal de Educacao, Ciencia e Tecnologia do Rio de Janeiro, Unidade Maracana, 20270-021, Rio de Janeiro-RJ, Brazil., de Carvalho CM; Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, Programa de Pos-graduacao em Patologia, 24033-900, Niteroi-RJ, Brazil., de Saules Silva LS; Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, Programa de Pos-graduacao em Patologia, 24033-900, Niteroi-RJ, Brazil., Dos S Velasco de Souza LC; Universidade Federal Fluminense, Instituto Biomedico, Programa de Posgraduacao em Microbiologia e Parasitologia Aplicadas, Niteroi, RJ, 24210-130, Brazil., Santana MV; Instituto de Biologia, Programa de Pos-graduacao em Ciencias e Biotecnologia, Universidade Federal Fluminense, 24210-130, Niteroi-RJ, Brazil., Martins NRC; Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, Programa de Pos-graduacao em Patologia, 24033-900, Niteroi-RJ, Brazil., Castro HC; Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, Programa de Pos-graduacao em Patologia, 24033-900, Niteroi-RJ, Brazil.; Instituto de Biologia, Programa de Pos-graduacao em Ciencias e Biotecnologia, Universidade Federal Fluminense, 24210-130, Niteroi-RJ, Brazil., Ferreira VF; Departamento de Tecnologia Farmaceutica, Faculdade de Farmacia, Universidade Federal Fluminense, 24241- 000, Niteroi-RJ, Brazil., Gonzaga DTG; Fundacao Centro Universitario Estadual da Zona Oeste, Unidade de Farmacia, 23070-200, Rio de Janeiro-RJ, Brazil., de Resende GO; Instituto Federal de Educacao, Ciencia e Tecnologia do Rio de Janeiro, Unidade Maracana, 20270-021, Rio de Janeiro-RJ, Brazil., de C da Silva F; Instituto de Quimica, Departamento de Quimica Organica, Universidade Federal Fluminense, 24210-141, Niteroi-RJ, Brazil.
Jazyk:	angličtina
Zdroj:	Current topics in medicinal chemistry [Curr Top Med Chem] 2020; Vol. 20 (2), pp. 121-131.
DOI:	10.2174/1568026619666191210160342
Abstrakt:	Background: Antibacterial resistance is a serious public health problem infecting millions in the global population. Currently, there are few antimicrobials on the market against resistant bacterial infections. Therefore, there is an urgent need for new therapeutic options against these strains. Objective: In this study, we synthesized and evaluated ten Bis(2-hydroxynaphthalene-1,4-dione) against Gram-positive strains, including a hospital Methicillin-resistant (MRSA), and Gram-negative strains. Methods: The compounds were prepared by condensation of aldehydes and lawsone in the presence of different L-aminoacids as catalysts in very good yields. The compounds were submitted to antibacterial analysis through disk diffusion and Minimal Inhibitory Concentration (MIC) assays. Results: L-aminoacids have been shown to be efficient catalysts in the preparation of Bis(2- hydroxynaphthalene-1,4-dione) from 2-hydroxy-1,4-naphthoquinones and arylaldehydes in excellent yields of up to 96%. The evaluation of the antibacterial profile against Gram-positive strains (Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, S. epidermidis ATCC 12228) also including a hospital Methicillin-resistant S. aureus (MRSA) and Gram-negative strains (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Klebsiella pneumoniae ATCC 4352), revealed that seven compounds showed antibacterial activity within the Clinical and Laboratory Standards Institute (CLSI) levels mainly against P. aeruginosa ATCC 27853 (MIC 8-128 µg/mL) and MRSA (MIC 32-128 µg/mL). In addition, the in vitro toxicity showed all derivatives with no hemolytic effects on healthy human erythrocytes. Furthermore, the derivatives showed satisfactory theoretical absorption, distribution, metabolism, excretion, toxicity (ADMET) parameters, and a similar profile to antibiotics currently in use. Finally, the in silico evaluation pointed to a structure-activity relationship related to lipophilicity for these compounds. This feature may help them in acting against Gram-negative strains, which present a rich lipid cell wall selective for several antibiotics. Conclusion: Our data showed the potential of this series for exploring new and more effective antibacterial activities in vivo against other resistant bacteria. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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