Nanoparticle Formulation of Indocyanine Green Improves Image-Guided Surgery in a Murine Model of Breast Cancer.

Autor: Wojtynek NE; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Olson MT; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Bielecki TA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., An W; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA., Bhat AM; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA., Band H; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.; Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE, USA., Lauer SR; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA., Silva-Lopez E; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA., Mohs AM; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. aaron.mohs@unmc.edu.; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. aaron.mohs@unmc.edu.; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA. aaron.mohs@unmc.edu.; Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE, USA. aaron.mohs@unmc.edu.
Jazyk: angličtina
Zdroj: Molecular imaging and biology [Mol Imaging Biol] 2020 Aug; Vol. 22 (4), pp. 891-903.
DOI: 10.1007/s11307-019-01462-y
Abstrakt: Purpose: Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green (ICG)-loaded self-assembled hyaluronic acid (HA) nanoparticles (NanoICG) for solid tumor imaging, which were shown to enhance intraoperative contrast.
Procedures: This study sought to assess the efficacy of NanoICG on completeness of breast tumor resection and post-surgical survival. BALB/c mice bearing iRFP + /luciferase + 4T1 syngeneic breast tumors were administered NanoICG or ICG, underwent FIGS, and were compared to bright light surgery (BLS) and sham controls.
Results: NanoICG increased the number of complete resections and improved tumor-free survival. This was a product of improved intraoperative contrast enhancement and the identification of a greater number of small, occult lesions than ICG and BLS. Additionally, NanoICG identified chest wall invasion and predicted recurrence in a model of late-stage breast cancer.
Conclusions: NanoICG is an efficacious intraoperative contrast agent and could potentially improve surgical outcomes in breast cancer.
Databáze: MEDLINE
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