Benzoazacrown compound: a highly effective chelator for therapeutic bismuth radioisotopes.

Autor: Matazova EV; Lomonosov Moscow State University , 119991 Leninskie Gory, 1/3 , Moscow , Russian Federation . Email: bayirta.egorova@gmail.com., Egorova BV; Lomonosov Moscow State University , 119991 Leninskie Gory, 1/3 , Moscow , Russian Federation . Email: bayirta.egorova@gmail.com., Konopkina EA; Lomonosov Moscow State University , 119991 Leninskie Gory, 1/3 , Moscow , Russian Federation . Email: bayirta.egorova@gmail.com., Aleshin GY; Lomonosov Moscow State University , 119991 Leninskie Gory, 1/3 , Moscow , Russian Federation . Email: bayirta.egorova@gmail.com., Zubenko AD; A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences , 119991 Vavilova, 28, GSP-1 , Moscow , Russian Federation., Mitrofanov AA; Lomonosov Moscow State University , 119991 Leninskie Gory, 1/3 , Moscow , Russian Federation . Email: bayirta.egorova@gmail.com.; Science Data Software , Rockville , MD , USA., Karpov KV; Science Data Software , Rockville , MD , USA., Fedorova OA; Lomonosov Moscow State University , 119991 Leninskie Gory, 1/3 , Moscow , Russian Federation . Email: bayirta.egorova@gmail.com.; A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences , 119991 Vavilova, 28, GSP-1 , Moscow , Russian Federation.; Mendeleev University of Chemistry and Technology of Russia , 125047 Miusskaya sqr., 9 , Moscow , Russian Federation., Fedorov YV; A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences , 119991 Vavilova, 28, GSP-1 , Moscow , Russian Federation., Kalmykov SN; Lomonosov Moscow State University , 119991 Leninskie Gory, 1/3 , Moscow , Russian Federation . Email: bayirta.egorova@gmail.com.; National Research Center 'Kurchatov Institute' , 123098 Akademika Kurchatova sqr., 1 , Moscow , Russian Federation.
Jazyk: angličtina
Zdroj: MedChemComm [Medchemcomm] 2019 Jul 04; Vol. 10 (9), pp. 1641-1645. Date of Electronic Publication: 2019 Jul 04 (Print Publication: 2019).
DOI: 10.1039/c9md00251k
Abstrakt: A new benzoazacrown ligand H 4 BATA was synthesized and its complexation ability towards bismuth cations was evaluated. Binding of cation occurs at room temperature in a few minutes and formed complex exhibits the same level of inertness as highly stable complex with the well-known H 4 DOTA in biologically relevant and challenging media under in vivo conditions.
(This journal is © The Royal Society of Chemistry 2019.)
Databáze: MEDLINE
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