Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis.
Autor: | Maharaj AR; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Wu H; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Zimmerman KO; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA., Speicher DG; Division of Pediatric Critical Care, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA., Sullivan JE; University of Louisville, Kosair Charities Pediatric Clinical Research Unit, and Norton Children's Hospital, Louisville, Kentucky, USA., Watt K; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA., Al-Uzri A; Oregon Health and Science University, Portland, Oregon, USA., Payne EH; The Emmes Company, LLC, Rockville, Maryland, USA., Erinjeri J; The Emmes Company, LLC, Rockville, Maryland, USA., Lin S; The Emmes Company, LLC, Rockville, Maryland, USA., Harper B; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Melloni C; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Hornik CP; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA. |
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Jazyk: | angličtina |
Zdroj: | Journal of clinical pharmacology [J Clin Pharmacol] 2020 May; Vol. 60 (5), pp. 636-647. Date of Electronic Publication: 2019 Dec 08. |
DOI: | 10.1002/jcph.1562 |
Abstrakt: | Differences in fentanyl pharmacokinetics (PK) between obese and nonobese adults have previously been reported; however, the impact of childhood obesity on fentanyl PK is relatively unknown. We developed a population pharmacokinetic (PopPK) model using opportunistically collected samples from a cohort of predominately obese children receiving fentanyl per the standard of care. Using a probability-based approach, we evaluated the ability of different continuous infusion strategies to provide steady-state concentrations (C (© 2019, The American College of Clinical Pharmacology.) |
Databáze: | MEDLINE |
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