Probing Medulloblastoma Initiation at the Single-Cell Level.

Autor:	Okonechnikov K; Hopp-Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Pfister SM; Hopp-Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany., Kutscher LM; Hopp-Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address: l.kutscher@kitz-heidelberg.de.
Jazyk:	angličtina
Zdroj:	Trends in cancer [Trends Cancer] 2019 Dec; Vol. 5 (12), pp. 759-761. Date of Electronic Publication: 2019 Oct 28.
DOI:	10.1016/j.trecan.2019.10.002
Abstrakt:	Medulloblastoma is a pediatric brain tumor arising from the developing cerebellum. Despite significant strides in classifying tumor subgroups and identifying underlying genetic mutations, progress in clinical outcomes has been notably slower. About 30% of patients experience relapse after treatment, possibly because of our inability to identify and eliminate the cancer stem cells. Zhang et al. recently investigated these cells in the SHH subgroup of medulloblastoma and identified drugs that may target them. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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