Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise.

Autor: Le Flecher A; Department of Nephrology - Transplantation, CHU de la Réunion Felix Guyon, Saint Denis, Réunion, France., Viallet N; Department of Nephrology - Transplantation, CHU de la Réunion Felix Guyon, Saint Denis, Réunion, France., Hebmann D; Department of Nephrology - Transplantation, CHU de la Réunion Felix Guyon, Saint Denis, Réunion, France., Chauveau B; Department of Pathology, CHU Necker-Enfants Malades, Paris, France., Vacher Coponat H; Department of Nephrology - Transplantation, CHU de la Réunion Felix Guyon, Saint Denis, Réunion, France.; Université de la Réunion, UFR Santé, Réunion, France.
Jazyk: angličtina
Zdroj: Clinical kidney journal [Clin Kidney J] 2019 Apr 23; Vol. 12 (6), pp. 801-802. Date of Electronic Publication: 2019 Apr 23 (Print Publication: 2019).
DOI: 10.1093/ckj/sfz044
Abstrakt: We report a 35-year-old man who suffered from recurrent macroscopic haematuria after intensive exercise. One episode was associated with bilateral loin (flank) pain and severe acute kidney injury. His kidney biopsy revealed an atypical anti-glomerular basement membrane (GBM) disease typified by bright linear GBM staining for monotypic immunoglobulin G but without a diffuse crescentic phenotype and no circulating anti-GBM antibody. Outcome was spontaneously favourable. The patient had no recurrence or urine abnormality without running. The original presentation emphasized that exercise could reveal an underlying glomerulopathy.
(© The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.)
Databáze: MEDLINE
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