Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.

Autor: Saunders KO; Human Vaccine Institute and Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA. kevin.saunders@duke.edu barton.haynes@duke.edu alt@enders.tch.harvard.edu.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA., Wiehe K; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Tian M; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Acharya P; Human Vaccine Institute and Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA., Bradley T; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Alam SM; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Go EP; Department of Chemistry, University of Kansas, Lawrence, KS 66049, USA., Scearce R; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Sutherland L; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Henderson R; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Hsu AL; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Borgnia MJ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Chen H; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Lu X; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Wu NR; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Watts B; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Jiang C; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Easterhoff D; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Cheng HL; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., McGovern K; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Waddicor P; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Chapdelaine-Williams A; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Eaton A; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Zhang J; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Rountree W; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Verkoczy L; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Tomai M; Corporate Research Materials Lab, 3M Company, St. Paul, MN 55144, USA., Lewis MG; Bioqual, Rockville, MD 20850, USA., Desaire HR; Department of Chemistry, University of Kansas, Lawrence, KS 66049, USA., Edwards RJ; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Cain DW; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Bonsignori M; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Montefiori D; Human Vaccine Institute and Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA., Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. kevin.saunders@duke.edu barton.haynes@duke.edu alt@enders.tch.harvard.edu., Haynes BF; Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA. kevin.saunders@duke.edu barton.haynes@duke.edu alt@enders.tch.harvard.edu.; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2019 Dec 06; Vol. 366 (6470).
DOI: 10.1126/science.aay7199
Databáze: MEDLINE