Diagnosis of Mycobacterium abscessus/chelonae complex cutaneous infection: Correlation of tissue culture and skin biopsy.

Autor: Sardiña LA; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.; Department of Dermatology, Cleveland Clinic, Cleveland, Ohio., Kaw U; Department of Dermatology, Cleveland Clinic, Cleveland, Ohio., Jour G; Department of Pathology and Dermatology, New York Langone Medical Center, New York, New York., Knabel D; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.; Department of Dermatology, Cleveland Clinic, Cleveland, Ohio., Dyck RM; Department of Dermatology, Cleveland Clinic, Cleveland, Ohio.; Skin Wellness Center Of Alabama, Birmingham, Alabama., Procop GW; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio., Bergfeld WF; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.; Department of Dermatology, Cleveland Clinic, Cleveland, Ohio., Harrington S; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio., Demkowicz R; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio., Piliang MP; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.; Department of Dermatology, Cleveland Clinic, Cleveland, Ohio.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2020 Apr; Vol. 47 (4), pp. 321-327. Date of Electronic Publication: 2019 Dec 19.
DOI: 10.1111/cup.13623
Abstrakt: Mycobacterium abscessus and M. chelonae belong to the rapid-growing nontuberculous mycobacteria (NTM) group, which are defined by their ability to form visible colonies on agar within 7 days of subculture. Cutaneous infections by this complex show a heterogeneous clinical presentation with varied histopathologic findings. However, the presence of vacuoles in many specimens has been reported as a specific histologic finding. Herein, we correlate the histopathology of patients with tissue-culture positive M. abscessus/M. chelonae complex in order to identify features that may prompt a rapid categorization of the infectious etiology. The cohort includes 33 skin punch biopsy specimens from 28 patients who had associated positive tissue cultures. The most frequent clinical presentation was a single or multiple nodule. Twenty-seven specimens (81.81%) were found to have vacuoles. The observation of certain histologic features (ie, polymorphonuclear microabscesses and epithelioid granuloma formation) should raise the possibility of infection by NTM. In addition to these findings, we believe the presence of vacuoles in the dermal and subcutaneous inflammation should raise suspicion for NTM.
(© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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