COMPARISON OF THE RADIATION SENSITIVITY OF THE BREAST CANCER CELL LINE MCF7 AND HUMAN ADIPOSE-DERIVED STEM CELLS.

Autor:	Michaelidesová A; Nuclear Physics Institute of the Czech Academy of Sciences, Řež 130, 25068 Řež, Czech Republic.; Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Břehová 7, 11519 Prague, Czech Republic., Vachelová J; Nuclear Physics Institute of the Czech Academy of Sciences, Řež 130, 25068 Řež, Czech Republic., Cupal L; Nuclear Physics Institute of the Czech Academy of Sciences, Řež 130, 25068 Řež, Czech Republic.; Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Břehová 7, 11519 Prague, Czech Republic.; Institute of Radiation Oncology of the Hospital Na Bulovce, Budínova 67/2, 18081 Prague, Czech Republic., Konířová J; Nuclear Physics Institute of the Czech Academy of Sciences, Řež 130, 25068 Řež, Czech Republic.; Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic., Brabcová KP; Nuclear Physics Institute of the Czech Academy of Sciences, Řež 130, 25068 Řež, Czech Republic., Bačáková L; Institute of Physiology of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic., Vandrovcová M; Institute of Physiology of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic., Davídková M; Nuclear Physics Institute of the Czech Academy of Sciences, Řež 130, 25068 Řež, Czech Republic.
Jazyk:	angličtina
Zdroj:	Radiation protection dosimetry [Radiat Prot Dosimetry] 2019 Dec 31; Vol. 186 (2-3), pp. 155-158.
DOI:	10.1093/rpd/ncz193
Abstrakt:	A comparison between breast cancer cell line MCF7 and human adipose-derived stem cells (ADSC) after irradiation by the same doses of megavoltage X-rays was performed. The cell growth, the induction of apoptosis and the expression of selected genes were analyzed. Irradiated MCF7 related to its control sample grows slower than ADSC and it undergoes apoptosis in much higher levels than ADSC. This was confirmed by real-time polymerase chain reaction as well, where the expression of apoptotic genes was found to be considerably higher for MCF7 than for ADSC. From the results of this project, it could be stated that MCF7 is more radiosensitive than ADSC. (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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