Normalized Cortisol Reactivity Predicts Future Neuropsychological Functioning in Children With Mild/Moderate Asthma.

Autor: Dinces SM; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Rowell LN; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Benson J; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Hile SN; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Tang AC; Faculty of Education, The University of Hong Kong, Pok Fu Lam, Hong Kong., Annett RD; Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, United States.
Jazyk: angličtina
Zdroj: Frontiers in psychology [Front Psychol] 2019 Nov 19; Vol. 10, pp. 2570. Date of Electronic Publication: 2019 Nov 19 (Print Publication: 2019).
DOI: 10.3389/fpsyg.2019.02570
Abstrakt: Cortisol reactivity to adrenocorticotropic hormone (ACTH) has been associated with neuropsychological processes including attention and memory in children with asthma. While cortisol reactivity to a psychological stressor is often considered a measure of current neuroendocrine functioning, this study examines the association of the cortisol reactivity and subsequent neuropsychological functioning. Using prospective data from the Childhood Asthma Management Program (CAMP), we explored the predictive ability of cortisol reactivity to ACTH and children's later attention and memory using traditional and an alternative cortisol reactivity (normalized cortisol) measures. Cortisol reactivity was assessed at study entry and 1-year follow-up, and neuropsychological functioning was assessed at 3-year follow-up. Cortisol reactivity was assessed through plasma cortisol concentrations collected at baseline (CORT BASELINE ) and 30 min post-ACTH challenge (CORT POST-A CTH ). An alternative measure of cortisol reactivity was developed through post-ACTH stimulation cortisol, normalized by cortisol by baseline (CORT NORM -ACTH ). CORT B ASELINE positively predicted year 3 attention, while CORT NORM -ACTH negatively predicted attention, suggesting convergence of cortisol variables in prediction of neuropsychological function. Year 1 CORT ACTH positively predicted child memory at year 3; Year 1 CORT NORM-ACTH negatively predicted year 3 sustained attentions. These findings demonstrate that HPA reactivity, including the application of normalized cortisol reactivity, can predict subsequent neuropsychological functioning of children with mild to moderate asthma.
(Copyright © 2019 Dinces, Rowell, Benson, Hile, Tang and Annett.)
Databáze: MEDLINE
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